4anb A 2.2 BS01 YQY A 1 K97 V127 I141 D208 F209 V211 L215 K40 V70 I84 D151 F152 V154 L158 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T169 2.7.12.2 0004672,0005524,0006468 -logKd/Ki=8.18, IC50=6.6nM IC50=6.6nM Q02750 24900486 501 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 4anb A 2.2 BS02 ACP A 1 L74 G75 G77 N78 V82 A95 M143 M146 S150 Q153 K192 S194 N195 L197 D208 L17 G18 G20 N21 V25 A38 M86 M89 S93 Q96 K135 S137 N138 L140 D151 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T169 2.7.12.2 0004672,0005524,0006468 Q02750 24900486 502 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 4anb A 2.2 BS03 MG A 1 N195 D208 N138 D151 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T169 2.7.12.2 0004672,0005524,0006468 Q02750 24900486 503 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL