4an9 A 2.8 BS01 ACP A 1 L74 G75 A76 G77 N78 A95 M143 M146 Q153 K192 S194 L197 L17 G18 A19 G20 N21 A38 M86 M89 Q96 K135 S137 L140 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T168 2.7.12.2 0004672,0005524,0006468 Q02750 24900486 1382 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 4an9 A 2.8 BS02 MG A 1 N195 D208 N138 D151 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T168 2.7.12.2 0004672,0005524,0006468 Q02750 24900486 1383 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 4an9 A 2.8 BS03 2P7 A 1 K97 L118 V127 I141 M143 D190 D208 F209 G210 V211 L215 K40 L61 V70 I84 M86 D133 D151 F152 G153 V154 L158 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T168 2.7.12.2 0004672,0005524,0006468 -logKd/Ki=7.36, IC50=44nM IC50=44nM Q02750 24900486 1384 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL