4an2 A 2.5 BS01 EUI A 1 N78 K97 V127 I141 D190 D208 F209 V211 S212 L215 G225 N21 K40 V70 I84 D133 D151 F152 V154 S155 L158 G168 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T169 2.7.12.2 0004672,0005524,0006468 -logKd/Ki=9.05, IC50=0.9nM IC50=4.2nM Q02750 24900486 1382 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 4an2 A 2.5 BS02 ACP A 1 L74 G75 G77 N78 V82 A95 M146 S150 Q153 K192 S194 N195 L197 D208 L17 G18 G20 N21 V25 A38 M89 S93 Q96 K135 S137 N138 L140 D151 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T169 2.7.12.2 0004672,0005524,0006468 Q02750 24900486 1383 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 4an2 A 2.5 BS03 MG A 1 N195 D208 N138 D151 D190 K192 S194 N195 D208 D217 T226 D133 K135 S137 N138 D151 D160 T169 2.7.12.2 0004672,0005524,0006468 Q02750 24900486 1384 MALGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL