3wig A 2.7 BS01 ANP A 1 L75 G76 A77 G78 A96 K98 M147 S151 Q154 K193 S195 L198 L14 G15 A16 G17 A32 K34 M83 S87 Q90 K129 S131 L134 D191 K193 S195 N196 D209 D218 T227 D127 K129 S131 N132 D145 D154 T163 2.7.12.2 0004672,0005524,0006468 Q02750 24746704 401 MELKDDDFEKISELGAGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 3wig A 2.7 BS02 MG A 1 N196 D209 N132 D145 D191 K193 S195 N196 D209 D218 T227 D127 K129 S131 N132 D145 D154 T163 2.7.12.2 0004672,0005524,0006468 Q02750 24746704 402 MELKDDDFEKISELGAGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 3wig A 2.7 BS03 CHU A 1 L119 V128 I142 M144 R190 D191 C208 D209 F210 G211 V212 L216 I217 M220 N222 L55 V64 I78 M80 R126 D127 C144 D145 F146 G147 V148 L152 I153 M156 N158 D191 K193 S195 N196 D209 D218 T227 D127 K129 S131 N132 D145 D154 T163 2.7.12.2 0004672,0005524,0006468 -logKd/Ki=8.64, Kd=2.30nM Q02750 24746704 403 MELKDDDFEKISELGAGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG