3we4 A 1.995 BS01 ZN A 1 C240 H245 H251 C254 C156 H161 H164 C167 D218 K220 E222 N223 D236 T256 D134 K136 E138 N139 D152 T169 2.7.11.1 0004672,0004674,0005524,0006468 P23443 25078151 401 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQ 3we4 A 1.995 BS02 5FI A 1 K99 G100 G103 V105 A121 K123 L125 E173 Y174 L175 M225 K241 K15 G16 G19 V21 A37 K39 L41 E89 Y90 L91 M141 K157 D218 K220 E222 N223 D236 T256 D134 K136 E138 N139 D152 T169 2.7.11.1 0004672,0004674,0005524,0006468 ic50=15nM -logKd/Ki=7.82, IC50=15nM Ki=20nM, IC50=160nM P23443 25078151 402 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQ