3tvc A 2.43 BS01 ZN A 1 H222 H226 H232 H119 H123 H129 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22689580 501 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDED 3tvc A 2.43 BS02 ZN A 2 H172 D174 H187 H200 H69 D71 H84 H97 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22689580 502 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDED 3tvc A 2.43 BS03 CA A 1 D128 D203 E205 D25 D100 E102 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22689580 503 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDED 3tvc A 2.43 BS04 CA A 2 D179 G180 S182 L184 D202 E205 D76 G77 S79 L81 D99 E102 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22689580 504 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDED 3tvc A 2.43 BS05 CA A 3 D162 N194 Y195 G196 D198 D59 N91 Y92 G93 D95 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22689580 505 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDED 3tvc A 2.43 BS06 E3P A 1 L184 L185 A186 L218 V219 H222 E223 H226 H232 L239 F241 I243 Y244 T245 T247 F252 L81 L82 A83 L115 V116 H119 E120 H123 H129 L136 F138 I140 Y141 T142 T144 F149 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=18nM -logKd/Ki=7.74, Ki=18nM Ki=18nM P45452 22689580 1 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDED