3thb A 2.5 BS01 ZN A 1 H93 C212 H52 C171 D176 K178 G180 N181 D194 T214 D135 K137 G139 N140 D153 T173 2.7.11.21 0004672,0005524,0006468 P53350 22070629 502 EVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIA 3thb A 2.5 BS02 3TA A 1 L59 G60 K61 C67 A80 L132 C133 R136 E140 F183 D194 L18 G19 K20 C26 A39 L91 C92 R95 E99 F142 D153 D176 K178 G180 N181 D194 T214 D135 K137 G139 N140 D153 T173 2.7.11.21 0004672,0005524,0006468 ic50=2nM -logKd/Ki=8.70, IC50=2nM P53350 22070629 1 EVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIA