3pka A 1.25 BS01 MN A 1 D142 H205 T236 E238 E269 D141 H204 T235 E237 E268 H114 D131 D142 G204 H205 G208 H212 L215 E238 N242 E269 H113 D130 D141 G203 H204 G207 H211 L214 E237 N241 E268 3.4.11.18 0004177,0004239,0005506,0005829,0006508,0008235,0016485,0046872,0046914,0050897,0070006 P9WK19 21465667 286 PSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTCL 3pka A 1.25 BS02 MN A 2 D131 D142 E269 D130 D141 E268 H114 D131 D142 G204 H205 G208 H212 L215 E238 N242 E269 H113 D130 D141 G203 H204 G207 H211 L214 E237 N241 E268 3.4.11.18 0004177,0004239,0005506,0005829,0006508,0008235,0016485,0046872,0046914,0050897,0070006 P9WK19 21465667 287 PSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTCL 3pka A 1.25 BS03 Y02 A 1 Y97 H114 D131 D142 T203 H205 F211 H212 E238 E269 Y96 H113 D130 D141 T202 H204 F210 H211 E237 E268 H114 D131 D142 G204 H205 G208 H212 L215 E238 N242 E269 H113 D130 D141 G203 H204 G207 H211 L214 E237 N241 E268 3.4.11.18 0004177,0004239,0005506,0005829,0006508,0008235,0016485,0046872,0046914,0050897,0070006 ic50=0.54uM -logKd/Ki=6.27, IC50=540nM P9WK19 21465667 288 PSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTCL