3nty A 1.87 BS01 NAP A 1 G22 T23 Y24 Y55 H117 Q190 Y216 S217 L219 S221 H222 L236 A253 L268 K270 S271 R276 Q279 N280 L306 G17 T18 Y19 Y50 H112 Q185 Y211 S212 L214 S216 H217 L231 A248 L263 K265 S266 R271 Q274 N275 L301 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.112,1.1.1.149,1.1.1.209,1.1.1.210,1.1.1.357,1.1.1.51,1.1.1.53,1.1.1.62,1.3.1.20 0001523,0004032,0004033,0004303,0005515,0005737,0005829,0006629,0006693,0006805,0007586,0008206,0015721,0016491,0016655,0030283,0030299,0030855,0031406,0032052,0033703,0033764,0035410,0042448,0042574,0042632,0044597,0044598,0046683,0047006,0047023,0047024,0047042,0047044,0047045,0047086,0047115,0047718,0070062,0071395,2000379 Q04828 21414777 351 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY 3nty A 1.87 BS02 5P3 A 1 Y24 L54 Y55 W86 H117 F118 H222 W227 L306 L308 F311 Y19 L49 Y50 W81 H112 F113 H217 W222 L301 L303 F306 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.112,1.1.1.149,1.1.1.209,1.1.1.210,1.1.1.357,1.1.1.51,1.1.1.53,1.1.1.62,1.3.1.20 0001523,0004032,0004033,0004303,0005515,0005737,0005829,0006629,0006693,0006805,0007586,0008206,0015721,0016491,0016655,0030283,0030299,0030855,0031406,0032052,0033703,0033764,0035410,0042448,0042574,0042632,0044597,0044598,0046683,0047006,0047023,0047024,0047042,0047044,0047045,0047086,0047115,0047718,0070062,0071395,2000379 Ki=0.86nM Ki=1.2nM, IC50=100nM Q04828 21414777 350 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY 3nty A 1.87 BS03 ZN A 1 H248 E292 H243 E287 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.112,1.1.1.149,1.1.1.209,1.1.1.210,1.1.1.357,1.1.1.51,1.1.1.53,1.1.1.62,1.3.1.20 0001523,0004032,0004033,0004303,0005515,0005737,0005829,0006629,0006693,0006805,0007586,0008206,0015721,0016491,0016655,0030283,0030299,0030855,0031406,0032052,0033703,0033764,0035410,0042448,0042574,0042632,0044597,0044598,0046683,0047006,0047023,0047024,0047042,0047044,0047045,0047086,0047115,0047718,0070062,0071395,2000379 Q04828 21414777 324 QCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY