3mo5 A 2.14 BS01 ZN A 1 C1031 C1044 C1074 C1078 C54 C67 C97 C101 Y1124 Y1211 Y147 Y231 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 1 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3mo5 A 2.14 BS02 ZN A 2 C1037 C1074 C1080 C1084 C60 C97 C103 C107 Y1124 Y1211 Y147 Y231 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 2 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3mo5 A 2.14 BS03 ZN A 3 C1031 C1033 C1037 C1042 C54 C56 C60 C65 Y1124 Y1211 Y147 Y231 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 3 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3mo5 A 2.14 BS04 ZN A 4 C1172 C1225 C1227 C1232 C192 C245 C247 C252 Y1124 Y1211 Y147 Y231 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 4 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3mo5 A 2.14 BS05 E72 A 1 D1131 A1134 D1135 R1137 D1140 L1143 D1145 Y1211 R1214 F1215 D154 A157 D158 R160 D163 L166 D168 Y231 R234 F235 Y1124 Y1211 Y147 Y231 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Kd=136nM -logKd/Ki=6.87, Kd=136nM IC50=100nM, Kd=136nM Q9H9B1 20434463 1236 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS