3ma3 A 2.3 BS01 peptide B 0 D128 F130 D131 I133 T134 K169 D170 E171 D202 T204 V206 G238 D239 E243 D90 F92 D93 I95 T96 K131 D132 E133 D164 T166 V168 G200 D201 E205 D167 K169 N172 D186 L193 T204 D129 K131 N134 D148 L155 T166 2.7.11.1 0004672,0004674,0005515,0005524,0005634,0005654,0005730,0005737,0005829,0005886,0006338,0006468,0006915,0008134,0016310,0022898,0030145,0043024,0043066,0043433,0044024,0045824,0045893,0046777,0046872,0050821,0060045,0070561,0071346,0090336,0106310,1902033,1904263,1905062,1990748 P11309 20400536 1 ~ 7 QYQVGPLLGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIGGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH 3ma3 A 2.3 BS02 01I A 1 A65 K67 V126 L174 I185 D186 A27 K29 V88 L136 I147 D148 D167 K169 N172 D186 L193 T204 D129 K131 N134 D148 L155 T166 2.7.11.1 0004672,0004674,0005515,0005524,0005634,0005654,0005730,0005737,0005829,0005886,0006338,0006468,0006915,0008134,0016310,0022898,0030145,0043024,0043066,0043433,0044024,0045824,0045893,0046777,0046872,0050821,0060045,0070561,0071346,0090336,0106310,1902033,1904263,1905062,1990748 ic50=60nM -logKd/Ki=7.22, IC50=60nM P11309 20400536 313 QYQVGPLLGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIGGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH