3m0i A 1.07 BS01 NAP A 1 G18 T19 W20 K21 D43 Y48 H110 W111 N160 Q183 Y209 S210 P211 L212 S214 P215 D216 A245 I260 P261 K262 S263 T265 R268 E271 N272 C298 G19 T20 W21 K22 D44 Y49 H111 W112 N161 Q184 Y210 S211 P212 L213 S215 P216 D217 A246 I261 P262 K263 S264 T266 R269 E272 N273 C299 D43 Y48 K77 H110 D44 Y49 K78 H111 1.1.1.21,1.1.1.300,1.1.1.372,1.1.1.54 0001523,0001758,0002070,0003091,0004032,0005515,0005615,0005654,0005737,0005739,0005829,0005975,0006629,0006693,0006700,0009055,0016491,0019853,0035809,0036130,0042572,0043066,0043795,0044597,0044598,0046370,0047655,0047939,0047956,0052650,0070062,0071475,0072205 P15121 21684320 500 MASRILLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPVGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF 3m0i A 1.07 BS02 ZST A 1 W20 Y48 H110 W111 V113 F122 W219 L300 Y309 P310 W21 Y49 H111 W112 V114 F123 W220 L301 Y310 P311 D43 Y48 K77 H110 D44 Y49 K78 H111 1.1.1.21,1.1.1.300,1.1.1.372,1.1.1.54 0001523,0001758,0002070,0003091,0004032,0005515,0005615,0005654,0005737,0005739,0005829,0005975,0006629,0006693,0006700,0009055,0016491,0019853,0035809,0036130,0042572,0043066,0043795,0044597,0044598,0046370,0047655,0047939,0047956,0052650,0070062,0071475,0072205 Kd=1.85uM IC50=3.1nM, Ki=19nM P15121 21684320 600 MASRILLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPVGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF