3fuh A 1.8 BS01 ZN A 1 H295 H299 E318 H292 H296 E315 E271 H295 E296 H299 E318 D375 Y383 E268 H292 E293 H296 E315 D372 Y380 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 P09960 19618939 701 VDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD 3fuh A 1.8 BS02 5H1 A 1 W311 F314 P374 A377 Y378 W308 F311 P371 A374 Y375 E271 H295 E296 H299 E318 D375 Y383 E268 H292 E293 H296 E315 D372 Y380 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 -logKd/Ki=2.70, IC50=2000uM IC50=>2000000nM P09960 19618939 710 VDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD 3fuh A 1.8 BS03 BES A 1 Q136 Y267 G268 G269 E271 H295 E296 H299 F314 E318 Y378 Y383 Q133 Y264 G265 G266 E268 H292 E293 H296 F311 E315 Y375 Y380 E271 H295 E296 H299 E318 D375 Y383 E268 H292 E293 H296 E315 D372 Y380 3.3.2.6,3.4.11.4 0003723,0004177,0004301,0004463,0005515,0005576,0005634,0005654,0005737,0005829,0006508,0006629,0006691,0008233,0008237,0008270,0010043,0019370,0019538,0043171,0043434,0045148,0046872,0060509,0070006,0070062,1904724,1904813 IC50=4000nM, Kd=2050nM, Ki=320nM P09960 19618939 720 VDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD