3e7b A 1.7 BS01 MN A 1 D64 H66 D92 D59 H61 D87 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D59 H61 D87 D90 R91 N119 H120 H168 R216 H243 3.1.3.16 0016787 P62136 18992256 400 SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA 3e7b A 1.7 BS02 MN A 2 D92 N124 H173 H248 D87 N119 H168 H243 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D59 H61 D87 D90 R91 N119 H120 H168 R216 H243 3.1.3.16 0016787 P62136 18992256 401 SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA 3e7b A 1.7 BS03 E7B A 1 R96 C127 I130 Y134 D197 W206 D220 R221 V223 H248 Y272 F276 R91 C122 I125 Y129 D192 W201 D215 R216 V218 H243 Y267 F271 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D59 H61 D87 D90 R91 N119 H120 H168 R216 H243 3.1.3.16 0016787 ic50=0.16nM -logKd/Ki=9.80, IC50=0.16nM P62136 18992256 500 SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA 3e7b A 1.7 BS04 AZI A 1 F257 F258 K260 R261 F252 F253 K255 R256 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D59 H61 D87 D90 R91 N119 H120 H168 R216 H243 3.1.3.16 0016787 P62136 18992256 503 SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA 3e7b A 1.7 BS05 AZI A 2 M190 R191 M185 R186 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D59 H61 D87 D90 R91 N119 H120 H168 R216 H243 3.1.3.16 0016787 P62136 18992256 504 SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA