3cqw A 2.0 BS01 peptide C 0 H194 E234 F236 D274 K276 E278 F309 C310 G311 T312 P313 E314 E341 H51 E91 F93 D131 K133 E135 F166 C167 G168 T169 P170 E171 E198 D274 K276 N279 D292 T312 D131 K133 N136 D149 T169 2.7.11.1 0004672,0004674,0005524,0006468 P31749 18456494 1 ~ 10 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMIERRPHFPQFDYSASS 3cqw A 2.0 BS02 MN A 1 E314 H354 E171 H211 D274 K276 N279 D292 T312 D131 K133 N136 D149 T169 2.7.11.1 0004672,0004674,0005524,0006468 P31749 18456494 1 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMIERRPHFPQFDYSASS 3cqw A 2.0 BS03 CQW A 1 A177 M227 A230 E234 E278 M281 D292 F438 A34 M84 A87 E91 E135 M138 D149 F295 D274 K276 N279 D292 T312 D131 K133 N136 D149 T169 2.7.11.1 0004672,0004674,0005524,0006468 ic50=42nM -logKd/Ki=7.38, IC50=42nM P31749 18456494 999 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMIERRPHFPQFDYSASS