2xni A 3.3 BS01 peptide C 0 T4 Y6 Q8 T10 R11 S20 E30 E32 V33 Q34 I35 V36 S37 T61 R62 T63 A65 R109 T5 Y7 Q9 T11 R12 S21 E31 E33 V34 Q35 I36 V37 S38 T62 R63 T64 A66 R110 H57 D81 G137 S139 H58 D82 G138 S140 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 20801653 20 ~ 40 GAPITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMR 2xni A 3.3 BS02 peptide D 0 T4 Y6 A7 T5 Y7 A8 H57 D81 G137 S139 H58 D82 G138 S140 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 20801653 21 ~ 36 GAPITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMR 2xni A 3.3 BS03 TR8 A 1 H57 L135 K136 G137 S139 R155 A156 A157 D168 H58 L136 K137 G138 S140 R156 A157 A158 D169 H57 D81 G137 S139 H58 D82 G138 S140 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 -logKd/Ki=7.37, IC50=43nM P27958 20801653 1181 GAPITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMR 2xni A 3.3 BS04 ZN A 1 C97 C99 C145 C98 C100 C146 H57 D81 G137 S139 H58 D82 G138 S140 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 20801653 1182 GAPITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMR 2xni A 3.3 BS05 MG A 1 A5 A111 A6 A112 H57 D81 G137 S139 H58 D82 G138 S140 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 20801653 1183 GAPITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMR