2x39 A 1.93 BS01 peptide C 0 E236 F238 D275 K277 E279 F310 C311 G312 T313 P314 Y316 E342 L348 E91 F93 D130 K132 E134 F165 C166 G167 T168 P169 Y171 E197 L203 D275 K277 N280 D293 T313 D130 K132 N135 D148 T168 2.7.11.1 0004672,0004674,0005524,0006468 P31751 20151677 3 ~ 12 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITQEMFEDFDYIADW 2x39 A 1.93 BS02 X39 A 1 G161 G164 V166 A179 K181 M229 E230 A232 E236 M282 D293 F439 G16 G19 V21 A34 K36 M84 E85 A87 E91 M137 D148 F294 D275 K277 N280 D293 T313 D130 K132 N135 D148 T168 2.7.11.1 0004672,0004674,0005524,0006468 ic50=2.2nM -logKd/Ki=8.66, IC50=2.2nM IC50=2.2nM P31751 20151677 1480 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITQEMFEDFDYIADW