2fzb A 1.5 BS01 NAP A 1 G18 T19 W20 K21 D43 Y48 H110 W111 N160 Q183 Y209 S210 P211 L212 S214 P215 D216 A245 I260 P261 K262 S263 V264 T265 R268 E271 N272 G19 T20 W21 K22 D44 Y49 H111 W112 N161 Q184 Y210 S211 P212 L213 S215 P216 D217 A246 I261 P262 K263 S264 V265 T266 R269 E272 N273 D43 Y48 K77 H110 D44 Y49 K78 H111 1.1.1.21,1.1.1.300,1.1.1.372,1.1.1.54 0001523,0001758,0002070,0003091,0004032,0005515,0005615,0005654,0005737,0005739,0005829,0005975,0006629,0006693,0006700,0009055,0016491,0019853,0035809,0036130,0042572,0043066,0043795,0044597,0044598,0046370,0047655,0047939,0047956,0052650,0070062,0071475,0072205 P15121 16952371 500 MASRILLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF 2fzb A 1.5 BS02 TOL A 1 W20 Y48 W79 H110 W111 F115 F122 L300 S302 W21 Y49 W80 H111 W112 F116 F123 L301 S303 D43 Y48 K77 H110 D44 Y49 K78 H111 1.1.1.21,1.1.1.300,1.1.1.372,1.1.1.54 0001523,0001758,0002070,0003091,0004032,0005515,0005615,0005654,0005737,0005739,0005829,0005975,0006629,0006693,0006700,0009055,0016491,0019853,0035809,0036130,0042572,0043066,0043795,0044597,0044598,0046370,0047655,0047939,0047956,0052650,0070062,0071475,0072205 IC50=10.0nM P15121 16952371 600 MASRILLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF 2fzb A 1.5 BS03 TOL A 2 F122 W219 L300 L301 S302 F123 W220 L301 L302 S303 D43 Y48 K77 H110 D44 Y49 K78 H111 1.1.1.21,1.1.1.300,1.1.1.372,1.1.1.54 0001523,0001758,0002070,0003091,0004032,0005515,0005615,0005654,0005737,0005739,0005829,0005975,0006629,0006693,0006700,0009055,0016491,0019853,0035809,0036130,0042572,0043066,0043795,0044597,0044598,0046370,0047655,0047939,0047956,0052650,0070062,0071475,0072205 IC50=10.0nM P15121 16952371 700 MASRILLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF 2fzb A 1.5 BS04 TOL A 3 W20 K21 S22 P23 F122 W21 K22 S23 P24 F123 D43 Y48 K77 H110 D44 Y49 K78 H111 1.1.1.21,1.1.1.300,1.1.1.372,1.1.1.54 0001523,0001758,0002070,0003091,0004032,0005515,0005615,0005654,0005737,0005739,0005829,0005975,0006629,0006693,0006700,0009055,0016491,0019853,0035809,0036130,0042572,0043066,0043795,0044597,0044598,0046370,0047655,0047939,0047956,0052650,0070062,0071475,0072205 IC50=10.0nM P15121 16952371 800 MASRILLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF