2a4r A 2.4 BS01 peptide B 0 T4 A5 Y6 A7 Q8 Q9 T10 R11 T19 S20 E30 E32 V33 Q34 I35 V36 S37 R62 T63 I64 A65 R109 T4 A5 Y6 A7 Q8 Q9 T10 R11 T19 S20 E30 E32 V33 Q34 I35 V36 S37 R62 T63 I64 A65 R109 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 16112862 20 ~ 41 APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMRS 2a4r A 2.4 BS02 peptide D 0 T4 A5 Y6 A7 Q8 T4 A5 Y6 A7 Q8 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 16112862 21 ~ 36 APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMRS 2a4r A 2.4 BS03 ZN A 1 C97 C99 C145 C97 C99 C145 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 16112862 301 APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMRS 2a4r A 2.4 BS04 BNH A 1 Q41 T42 H57 R123 I132 K136 G137 S139 R155 A156 A157 C159 Q41 T42 H57 R123 I132 K136 G137 S139 R155 A156 A157 C159 H57 D81 G137 S139 H57 D81 G137 S139 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 -logKd/Ki=7.82, Ki=15nM P27958 16112862 401 APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMRS