1yyz A 1.85 BS01 F6P A 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 R276 D112 N203 Y206 Y235 G237 M239 Y255 K265 R267 D68 D74 E97 E98 D118 L120 D121 E280 D59 D65 E88 E89 D109 L111 D112 E271 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 15767255 339 IVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1yyz A 1.85 BS02 MG A 1 E97 D118 L120 E88 D109 L111 D68 D74 E97 E98 D118 L120 D121 E280 D59 D65 E88 E89 D109 L111 D112 E271 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 15767255 340 IVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1yyz A 1.85 BS03 MG A 2 D118 D121 E280 D109 D112 E271 D68 D74 E97 E98 D118 L120 D121 E280 D59 D65 E88 E89 D109 L111 D112 E271 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 15767255 341 IVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA 1yyz A 1.85 BS04 AMP A 1 V17 E20 G21 A24 T27 E29 M30 Y113 R140 M177 V8 E11 G12 A15 T18 E20 M21 Y104 R131 M168 D68 D74 E97 E98 D118 L120 D121 E280 D59 D65 E88 E89 D109 L111 D112 E271 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 Kd=2.4uM IC50=1300nM P00636 15767255 435 IVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHA