1xnz A 1.52 BS01 MN A 1 D97 D108 E235 D96 D107 E234 H79 D97 D108 H171 R175 H178 Q182 E204 N208 Q233 E235 H78 D96 D107 H170 R174 H177 Q181 E203 N207 Q232 E234 3.4.11.18 0004177,0004239,0005829,0006508,0008198,0008235,0046872,0046914,0070006 P0AE18 15506752 265 AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD 1xnz A 1.52 BS02 MN A 2 D108 H171 T202 E204 E235 D107 H170 T201 E203 E234 H79 D97 D108 H171 R175 H178 Q182 E204 N208 Q233 E235 H78 D96 D107 H170 R174 H177 Q181 E203 N207 Q232 E234 3.4.11.18 0004177,0004239,0005829,0006508,0008198,0008235,0046872,0046914,0070006 P0AE18 15506752 266 AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD 1xnz A 1.52 BS03 FCD A 1 Y62 H63 Y65 H79 D97 D108 H171 H178 E204 W221 E235 Y61 H62 Y64 H78 D96 D107 H170 H177 E203 W220 E234 H79 D97 D108 H171 R175 H178 Q182 E204 N208 Q233 E235 H78 D96 D107 H170 R174 H177 Q181 E203 N207 Q232 E234 3.4.11.18 0004177,0004239,0005829,0006508,0008198,0008235,0046872,0046914,0070006 ic50=0.24uM -logKd/Ki=6.62, IC50=0.24uM IC50=116000nM P0AE18 15506752 268 AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD