1xh9 A 1.64 BS01 peptide B 0 E84 H87 E127 F129 R133 E170 T197 L198 C199 G200 E203 E230 Y235 P236 F239 D241 I246 D328 Y330 E72 H75 E115 F117 R121 E158 T185 L186 C187 G188 E191 E218 Y223 P224 F227 D229 I234 D316 Y318 D166 K168 E170 N171 D184 T201 D154 K156 E158 N159 D172 T189 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 15634010 5 ~ 24 ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKEIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLMIDQQGYIKVTDFGLAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 1xh9 A 1.64 BS02 R69 A 1 G50 T51 G52 F54 V57 A70 K72 L74 E84 E91 A123 E127 E170 N171 M173 T183 D184 G186 F327 G38 T39 G40 F42 V45 A58 K60 L62 E72 E79 A111 E115 E158 N159 M161 T171 D172 G174 F315 D166 K168 E170 N171 D184 T201 D154 K156 E158 N159 D172 T189 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 Kd=17nM -logKd/Ki=7.77, Kd=17nM IC50=30nM P00517 15634010 351 ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKEIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLMIDQQGYIKVTDFGLAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 1xh9 A 1.64 BS03 BU3 A 1 P141 R144 T299 T300 P129 R132 T287 T288 D166 K168 E170 N171 D184 T201 D154 K156 E158 N159 D172 T189 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 15634010 951 ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKEIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLMIDQQGYIKVTDFGLAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 1xh9 A 1.64 BS04 BU3 A 2 F54 G55 R56 I73 D75 N115 F42 G43 R44 I61 D63 N103 D166 K168 E170 N171 D184 T201 D154 K156 E158 N159 D172 T189 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 15634010 952 ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKEIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLMIDQQGYIKVTDFGLAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 1xh9 A 1.64 BS05 BU3 A 3 E155 N289 K292 E143 N277 K280 D166 K168 E170 N171 D184 T201 D154 K156 E158 N159 D172 T189 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 15634010 953 ESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKEIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLMIDQQGYIKVTDFGLAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF