1wu1 A 2.3 BS01 CA A 1 D70 N72 Q75 E76 E77 E80 D56 N58 Q61 E62 E63 E66 H57 D102 Q192 G193 D194 S195 G196 H42 D88 Q182 G183 D184 S185 G186 3.4.21.6 0004252,0006508 P00742 15911309 261 IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMK 1wu1 A 2.3 BS02 CA A 2 Y185 D185A R222 K224 Y173 D174 R211 K214 H57 D102 Q192 G193 D194 S195 G196 H42 D88 Q182 G183 D184 S185 G186 3.4.21.6 0004252,0006508 P00742 15911309 262 IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMK 1wu1 A 2.3 BS03 D91 A 1 E97 T98 Y99 F174 D189 A190 Q192 V213 W215 G216 G218 C220 G226 I227 Y228 E83 T84 Y85 F162 D179 A180 Q182 V203 W205 G206 G208 C209 G216 I217 Y218 H57 D102 Q192 G193 D194 S195 G196 H42 D88 Q182 G183 D184 S185 G186 3.4.21.6 0004252,0006508 ic50=18nM -logKd/Ki=7.74, IC50=18nM P00742 15911309 700 IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMK