1it6 A 2.0 BS01 MN A 1 D64 H66 D92 D58 H60 D86 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000070,0000165,0000775,0000776,0000781,0001824,0003723,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005829,0005856,0005925,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P36873 12015153 401 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA 1it6 A 2.0 BS02 MN A 2 D92 N124 H173 H248 D86 N118 H167 H242 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000070,0000165,0000775,0000776,0000781,0001824,0003723,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005829,0005856,0005925,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P36873 12015153 402 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA 1it6 A 2.0 BS03 CYU A 1 S129 Y134 V195 P196 D197 W206 D208 R221 V223 Q249 Y272 S123 Y128 V189 P190 D191 W200 D202 R215 V217 Q243 Y266 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000070,0000165,0000775,0000776,0000781,0001824,0003723,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005829,0005856,0005925,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 Ki=4.1nM -logKd/Ki=8.39, Ki=4.1nM P36873 12015153 501 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA