1hw5 A 1.82 BS01 CMP A 1 S62 I70 G71 E72 L73 R82 S83 R123 L127 S62 I70 G71 E72 L73 R82 S83 R123 L127 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 Kb=2.0+-0.3M^-1 (11124966) P0ACJ8 11124966 210 VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVLAEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 1hw5 A 1.82 BS02 CMP A 2 K57 E58 Q170 Q174 G177 C178 S179 R180 K57 E58 Q170 Q174 G177 C178 S179 R180 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 Kb=2.0+-0.3M^-1 (11124966) P0ACJ8 11124966 211 VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVLAEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGT 1hw5 B 1.82 BS01 CMP A 2 A135 F136 A135 F136 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 Kb=2.0+-0.3M^-1 (11124966) P0ACJ8 11124966 211 VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVLAEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1hw5 B 1.82 BS02 CMP B 1 V49 I70 G71 E72 L73 R82 S83 A84 R123 V49 I70 G71 E72 L73 R82 S83 A84 R123 ? 0003677,0003680,0003700,0005515,0005829,0006351,0006355,0008301,0030552,0032993,0042802,0043565,0045013,0045892,0045893 Kb=2.0+-0.3M^-1 (11124966) P0ACJ8 11124966 210 VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVLAEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVV 1o9f A 2.7 BS01 peptide P 0 R63 R67 K129 R136 Y137 L181 N182 V185 E189 D232 N233 W237 S239 R59 R63 K125 R132 Y133 L177 N178 V181 E185 D224 N225 W229 S231 ? 0005737,0007165,0008104 Kd=0.7uM (12606564) P93343 12606564 1 ~ 5 PTAREENVYMAKLAEQAERYEEMVEFMEKVSNSLGSEELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNEEHVNSIREYRSKIENELSKICDGILKLLDAKLIPSAASGDSKVFYLKMKGDYHRYLAEFKTGAERKEAAESTLTAYKAAQDIATTELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELDTLYKDSTLIMQLLRDNLTLWTS 1o9f A 2.7 BS02 FSC A 1 N49 V53 F126 K129 I175 K221 D222 N45 V49 F122 K125 I171 K213 D214 ? 0005737,0007165,0008104 Kd=0.7uM (12606564) P93343 12606564 1240 PTAREENVYMAKLAEQAERYEEMVEFMEKVSNSLGSEELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNEEHVNSIREYRSKIENELSKICDGILKLLDAKLIPSAASGDSKVFYLKMKGDYHRYLAEFKTGAERKEAAESTLTAYKAAQDIATTELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELDTLYKDSTLIMQLLRDNLTLWTS 1w25 A 2.7 BS01 MG A 1 D9 D10 D53 M55 D8 D9 D52 M54 2.7.7.65 0000160,0005525,0005737,0005886,0016740,0030154,0043709,0046872,0052621,1902201 Ki=0.5uM (15569936) B8GZM2 15569936 500 SARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMDGFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLTRFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPVIESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRMVKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNRRYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRAIDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAKASGRNAVVGKAAH 1w25 A 2.7 BS02 C2E A 1 N335 D344 G369 E370 N334 D343 G368 E369 2.7.7.65 0000160,0005525,0005737,0005886,0016740,0030154,0043709,0046872,0052621,1902201 Ki=0.5uM (15569936) -logKd/Ki=6.30, Ki=0.5uM B8GZM2 15569936 501 SARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMDGFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLTRFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPVIESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRMVKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNRRYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRAIDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAKASGRNAVVGKAAH 1w25 A 2.7 BS03 C2E A 2 R178 R359 D362 D383 I387 R390 R177 R358 D361 D382 I386 R389 2.7.7.65 0000160,0005525,0005737,0005886,0016740,0030154,0043709,0046872,0052621,1902201 Ki=0.5uM (15569936) -logKd/Ki=6.30, Ki=0.5uM B8GZM2 15569936 503 SARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMDGFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLTRFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPVIESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRMVKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNRRYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRAIDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAKASGRNAVVGKAAH 1w25 A 2.7 BS04 C2E A 3 R148 V175 R178 S356 R359 A360 R390 R147 V174 R177 S355 R358 A359 R389 2.7.7.65 0000160,0005525,0005737,0005886,0016740,0030154,0043709,0046872,0052621,1902201 Ki=0.5uM (15569936) -logKd/Ki=6.30, Ki=0.5uM B8GZM2 15569936 505 SARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMDGFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLTRFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPVIESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRMVKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNRRYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRAIDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAKASGRNAVVGKAAH 1w25 B 2.7 BS01 MG B 1 D9 D10 D53 M55 D8 D9 D52 M54 2.7.7.65 0000160,0005525,0005737,0005886,0016740,0030154,0043709,0046872,0052621,1902201 Ki=0.5uM (15569936) B8GZM2 15569936 500 SARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMDGFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLTRFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPVIESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRMVKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNRRYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRAIDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAKASGRNAVVGKAAH 1w25 B 2.7 BS02 C2E B 1 R178 R359 D362 D383 I387 R390 R177 R358 D361 D382 I386 R389 2.7.7.65 0000160,0005525,0005737,0005886,0016740,0030154,0043709,0046872,0052621,1902201 Ki=0.5uM (15569936) B8GZM2 15569936 503 SARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMDGFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLTRFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPVIESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRMVKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNRRYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRAIDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAKASGRNAVVGKAAH 1w25 B 2.7 BS03 C2E B 2 R148 V175 R178 S356 R359 A360 R390 R147 V174 R177 S355 R358 A359 R389 2.7.7.65 0000160,0005525,0005737,0005886,0016740,0030154,0043709,0046872,0052621,1902201 Ki=0.5uM (15569936) B8GZM2 15569936 505 SARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMDGFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLTRFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPVIESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRMVKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNRRYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRAIDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAKASGRNAVVGKAAH 1xui A 1.5 BS01 CA A 1 E70 N72 V75 V76 E80 E52 N54 V57 V58 E62 H57 D102 Q192 G193 D194 S195 G196 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 Ki=19uM (9468142) P00760 9468142 247 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 1xui A 1.5 BS02 BAO A 1 H57 D189 S190 Q192 S195 V213 G219 H40 D171 S172 Q174 S177 V191 G196 H57 D102 Q192 G193 D194 S195 G196 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 Ki=19uM (9468142) P00760 9468142 246 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 2o99 A 1.7 BS01 GOA A 1 L60 S65 G66 D118 C128 S145 S147 L60 S65 G66 D114 C124 S141 S143 ? Kd=0.9+-2uM (17426033) P16528 17426033 902 GHMSRNLLAIVHPILRNLMEESGETVNMAVLDQSDHEAIIIDQVQCTHLMRMSAPIGGKLPMHASGAGKAFLAQLSEEQVTKKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCLAACIFDEHREPFAAISISGPISRITDDRVTEFGAMVIKAAKEVTLAYGGMRGS 2o99 B 1.7 BS01 GOA B 1 S65 G66 D118 C128 S145 S147 S65 G66 D118 C128 S145 S147 ? Kd=0.9+-2uM (17426033) P16528 17426033 903 GHMSRNLLAIVHPILRNLMEESGETVNMAVLDQSDHEAIIIDQVQCTHLMRMSAPIGGKLPMHASGAGKAFLAQLSEEQVTKLLHRKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCLAACIFDEHREPFAAISISGPISRITDDRVTEFGAMVIKAAKEVTLAYGGM 2o99 C 1.7 BS01 GOA C 1 S65 G66 D118 C128 S145 S147 S65 G66 D118 C128 S145 S147 ? Kd=0.9+-2uM (17426033) P16528 17426033 904 GHMSRNLLAIVHPILRNLMEESGETVNMAVLDQSDHEAIIIDQVQCTHLMRMSAPIGGKLPMHASGAGKAFLAQLSEEQVTKLLHRKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCLAACIFDEHREPFAAISISGPISRITDDRVTEFGAMVIKAAKEVTLAYGGMRGS 2o99 D 1.7 BS01 GOA D 1 S65 G66 D118 C128 S145 S147 S63 G64 D116 C126 S143 S145 ? Kd=0.9+-2uM (17426033) P16528 17426033 901 MSRNLLAIVHPILRNLMEESGETVNMAVLDQSDHEAIIIDQVQCTHLMRMSAPIGGKLPMHASGAGKAFLAQLSEEQVTKLLHRKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCLAACIFDEHREPFAAISISGPISRITDDRVTEFGAMVIKAAKEVTLAYGGMR 2our A 1.45 BS01 CMP A 1 H525 L635 L675 I692 F696 M713 Q726 F729 H79 L189 L229 I246 F250 M267 Q280 F283 3.1.4.17 0004114,0007165,0008081 Km=56nM (17389385) Q9Y233 17389385 778 HMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACALCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE 2ouy A 1.9 BS01 ZN A 1 H529 H563 N564 D674 H83 H117 N118 D228 3.1.4.17 0004114,0007165,0008081 Km=56nM (17389385) Q9Y233 17389385 777 HMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHNLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWIS 2ouy A 1.9 BS02 CMP A 1 H525 L635 I692 F696 Q726 F729 H79 L189 I246 F250 Q280 F283 3.1.4.17 0004114,0007165,0008081 Km=56nM (17389385) Q9Y233 17389385 779 HMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHNLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWIS 2oz6 A 2.8 BS01 CMP A 1 R59 E60 Q175 G178 R179 G182 C183 S184 R185 R52 E53 Q163 G166 R167 G170 C171 S172 R173 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 Kd=1.0uM (21665969) -logKd/Ki=5.26, Kd=5.5uM P55222 21665969 302 MKLKHLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFGT 2oz6 A 2.8 BS02 CMP A 2 I51 I63 F72 G73 E74 L75 R87 S88 A89 V91 R128 T132 I44 I56 F65 G66 E67 L68 R75 S76 A77 V79 R116 T120 ? 0000976,0001216,0001217,0003677,0003700,0005829,0006351,0006355,0030552,0032993,0043565,0045892,0045893 Kd=1.0uM (21665969) -logKd/Ki=5.26, Kd=5.5uM P55222 21665969 301 MKLKHLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFGT 2ptm A 1.93 BS01 CMP A 1 I592 T601 F609 G610 E611 I612 C613 R620 V621 R661 I122 T131 F139 G140 E141 I142 C143 R150 V151 R191 ? K1/2=1.1uM (17562314) O76977 17562314 401 DSSSRQYREKLKQVEEYMQYRKLPSHLRNKILDYYEYRYRGKMFDERHIFREVSESIRQDVANYNCRDLVASVPFFVGADSNFVTRVVTLLEFEVFQPADYVIQEGTFGDRMFFIQQGIVDIIMSDGVIATSLSDGSYFGEICLLTRERRVASVKCETYCTLFSLSVQHFNQVLDEFPAMRKTMEEIAVRRL 2pw3 A 1.56 BS01 ZN A 1 H164 H200 N201 D318 H79 H115 N116 D233 3.1.4.53 0004114,0007165,0008081 Km=56nM (17562314) Q08499 17582435 501 TEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHNVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ 2pw3 A 1.56 BS02 CMP A 1 H160 M273 L319 I336 Q369 F372 H75 M188 L234 I251 Q284 F287 3.1.4.53 0004114,0007165,0008081 Km=56nM (17562314) Q08499 17582435 1 TEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHNVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ 2pw3 B 1.56 BS01 ZN B 1 H164 H200 N201 D318 H77 H113 N114 D231 3.1.4.53 0004114,0007165,0008081 Km=56nM (17562314) Q08499 17582435 501 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHNVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ 2pw3 B 1.56 BS02 CMP B 1 H160 M273 L319 I336 Q369 F372 H73 M186 L232 I249 Q282 F285 3.1.4.53 0004114,0007165,0008081 Km=56nM (17562314) Q08499 17582435 1 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHNVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ 3auj A 2.1 BS01 GOL A 1 H143 E170 T222 Q296 D335 Q336 F374 H143 E170 T222 Q296 D335 Q336 F374 Q141 H143 E170 E221 Q296 D335 S362 Q141 H143 E170 E221 Q296 D335 S362 4.2.1.28 0003824,0016829,0016836,0031419,0046872,0050215 Km=1.2+-0.2mM (22221669) Q59470 22221669 1602 MRSKRFEALAKRPVNQDGFVKEWIEEGFIAMESPNDPKPSIKIVNGAVTELDGKPVSDFDLIDHFIARYGINLNRAEEVMAMDSVKLANMLCDPNVKRSEIVPLTTAMTPAKIVEVVSHMNVVEMMMAMQKMRARRTPSQQAHVTNVKDNPVQIAADAAEGAWRGFDEQETTVAVARYAPFNAIALLVGSQVGRPGVLTQCSLEEATELKLGMLGHTCYAETISVYGTEPVFTDGDDTPWSKGFLASSYASRGLKMRFTSGSGSEVQMGYAEGKSMLYLEARCIYITKAAGVQGLQNGSVSCIGVPSAVPSGIRAVLAENLICSSLDLECASSNDQTFTHSDMRRTARLLMQFLPGTDFISSGYSAVPNYDNMFAGSNEDAEDFDDYNVIQRDLKVDGGLRPVREEDVIAIRNKAARALQAVFAGMGLPPITDEEVEAATYAHGSKDMPERNIVEDIKFAQEIINKNRNGLEVVKALAQGGFTDVAQDMLNIQKAKLTGDYLHTSAIIVGDGQVLSAVNDVNDYAGPATGYRLQGERWEEIKNIPGALDPNE 3auj A 2.1 BS02 CA A 1 Q141 E170 E221 Q296 S362 Q141 E170 E221 Q296 S362 Q141 H143 E170 E221 Q296 D335 S362 Q141 H143 E170 E221 Q296 D335 S362 4.2.1.28 0003824,0016829,0016836,0031419,0046872,0050215 Km=1.2+-0.2mM (22221669) Q59470 22221669 1603 MRSKRFEALAKRPVNQDGFVKEWIEEGFIAMESPNDPKPSIKIVNGAVTELDGKPVSDFDLIDHFIARYGINLNRAEEVMAMDSVKLANMLCDPNVKRSEIVPLTTAMTPAKIVEVVSHMNVVEMMMAMQKMRARRTPSQQAHVTNVKDNPVQIAADAAEGAWRGFDEQETTVAVARYAPFNAIALLVGSQVGRPGVLTQCSLEEATELKLGMLGHTCYAETISVYGTEPVFTDGDDTPWSKGFLASSYASRGLKMRFTSGSGSEVQMGYAEGKSMLYLEARCIYITKAAGVQGLQNGSVSCIGVPSAVPSGIRAVLAENLICSSLDLECASSNDQTFTHSDMRRTARLLMQFLPGTDFISSGYSAVPNYDNMFAGSNEDAEDFDDYNVIQRDLKVDGGLRPVREEDVIAIRNKAARALQAVFAGMGLPPITDEEVEAATYAHGSKDMPERNIVEDIKFAQEIINKNRNGLEVVKALAQGGFTDVAQDMLNIQKAKLTGDYLHTSAIIVGDGQVLSAVNDVNDYAGPATGYRLQGERWEEIKNIPGALDPNE 3auj A 2.1 BS03 B12 B 1 T172 V173 S202 E205 Q267 M268 S301 M373 F374 T172 V173 S202 E205 Q267 M268 S301 M373 F374 Q141 H143 E170 E221 Q296 D335 S362 Q141 H143 E170 E221 Q296 D335 S362 4.2.1.28 0003824,0016829,0016836,0031419,0046872,0050215 Km=1.2+-0.2mM (22221669) Q59470 22221669 1601 MRSKRFEALAKRPVNQDGFVKEWIEEGFIAMESPNDPKPSIKIVNGAVTELDGKPVSDFDLIDHFIARYGINLNRAEEVMAMDSVKLANMLCDPNVKRSEIVPLTTAMTPAKIVEVVSHMNVVEMMMAMQKMRARRTPSQQAHVTNVKDNPVQIAADAAEGAWRGFDEQETTVAVARYAPFNAIALLVGSQVGRPGVLTQCSLEEATELKLGMLGHTCYAETISVYGTEPVFTDGDDTPWSKGFLASSYASRGLKMRFTSGSGSEVQMGYAEGKSMLYLEARCIYITKAAGVQGLQNGSVSCIGVPSAVPSGIRAVLAENLICSSLDLECASSNDQTFTHSDMRRTARLLMQFLPGTDFISSGYSAVPNYDNMFAGSNEDAEDFDDYNVIQRDLKVDGGLRPVREEDVIAIRNKAARALQAVFAGMGLPPITDEEVEAATYAHGSKDMPERNIVEDIKFAQEIINKNRNGLEVVKALAQGGFTDVAQDMLNIQKAKLTGDYLHTSAIIVGDGQVLSAVNDVNDYAGPATGYRLQGERWEEIKNIPGALDPNE 3auj L 2.1 BS01 GOL L 1 H143 E170 T222 Q296 D335 Q336 F374 H143 E170 T222 Q296 D335 Q336 F374 Q141 H143 E170 E221 Q296 D335 S362 Q141 H143 E170 E221 Q296 D335 S362 4.2.1.28 0003824,0016829,0016836,0031419,0046872,0050215 Km=1.2+-0.2mM (22221669) Q59470 22221669 2602 MRSKRFEALAKRPVNQDGFVKEWIEEGFIAMESPNDPKPSIKIVNGAVTELDGKPVSDFDLIDHFIARYGINLNRAEEVMAMDSVKLANMLCDPNVKRSEIVPLTTAMTPAKIVEVVSHMNVVEMMMAMQKMRARRTPSQQAHVTNVKDNPVQIAADAAEGAWRGFDEQETTVAVARYAPFNAIALLVGSQVGRPGVLTQCSLEEATELKLGMLGHTCYAETISVYGTEPVFTDGDDTPWSKGFLASSYASRGLKMRFTSGSGSEVQMGYAEGKSMLYLEARCIYITKAAGVQGLQNGSVSCIGVPSAVPSGIRAVLAENLICSSLDLECASSNDQTFTHSDMRRTARLLMQFLPGTDFISSGYSAVPNYDNMFAGSNEDAEDFDDYNVIQRDLKVDGGLRPVREEDVIAIRNKAARALQAVFAGMGLPPITDEEVEAATYAHGSKDMPERNIVEDIKFAQEIINKNRNGLEVVKALAQGGFTDVAQDMLNIQKAKLTGDYLHTSAIIVGDGQVLSAVNDVNDYAGPATGYRLQGERWEEIKNIPGALDPN 3auj L 2.1 BS02 CA L 1 Q141 E170 E221 Q296 S362 Q141 E170 E221 Q296 S362 Q141 H143 E170 E221 Q296 D335 S362 Q141 H143 E170 E221 Q296 D335 S362 4.2.1.28 0003824,0016829,0016836,0031419,0046872,0050215 Km=1.2+-0.2mM (22221669) Q59470 22221669 2603 MRSKRFEALAKRPVNQDGFVKEWIEEGFIAMESPNDPKPSIKIVNGAVTELDGKPVSDFDLIDHFIARYGINLNRAEEVMAMDSVKLANMLCDPNVKRSEIVPLTTAMTPAKIVEVVSHMNVVEMMMAMQKMRARRTPSQQAHVTNVKDNPVQIAADAAEGAWRGFDEQETTVAVARYAPFNAIALLVGSQVGRPGVLTQCSLEEATELKLGMLGHTCYAETISVYGTEPVFTDGDDTPWSKGFLASSYASRGLKMRFTSGSGSEVQMGYAEGKSMLYLEARCIYITKAAGVQGLQNGSVSCIGVPSAVPSGIRAVLAENLICSSLDLECASSNDQTFTHSDMRRTARLLMQFLPGTDFISSGYSAVPNYDNMFAGSNEDAEDFDDYNVIQRDLKVDGGLRPVREEDVIAIRNKAARALQAVFAGMGLPPITDEEVEAATYAHGSKDMPERNIVEDIKFAQEIINKNRNGLEVVKALAQGGFTDVAQDMLNIQKAKLTGDYLHTSAIIVGDGQVLSAVNDVNDYAGPATGYRLQGERWEEIKNIPGALDPN 3auj L 2.1 BS03 B12 E 1 T172 V173 S202 E205 S224 Q267 M268 S301 M373 F374 T172 V173 S202 E205 S224 Q267 M268 S301 M373 F374 Q141 H143 E170 E221 Q296 D335 S362 Q141 H143 E170 E221 Q296 D335 S362 4.2.1.28 0003824,0016829,0016836,0031419,0046872,0050215 Km=1.2+-0.2mM (22221669) Q59470 22221669 2601 MRSKRFEALAKRPVNQDGFVKEWIEEGFIAMESPNDPKPSIKIVNGAVTELDGKPVSDFDLIDHFIARYGINLNRAEEVMAMDSVKLANMLCDPNVKRSEIVPLTTAMTPAKIVEVVSHMNVVEMMMAMQKMRARRTPSQQAHVTNVKDNPVQIAADAAEGAWRGFDEQETTVAVARYAPFNAIALLVGSQVGRPGVLTQCSLEEATELKLGMLGHTCYAETISVYGTEPVFTDGDDTPWSKGFLASSYASRGLKMRFTSGSGSEVQMGYAEGKSMLYLEARCIYITKAAGVQGLQNGSVSCIGVPSAVPSGIRAVLAENLICSSLDLECASSNDQTFTHSDMRRTARLLMQFLPGTDFISSGYSAVPNYDNMFAGSNEDAEDFDDYNVIQRDLKVDGGLRPVREEDVIAIRNKAARALQAVFAGMGLPPITDEEVEAATYAHGSKDMPERNIVEDIKFAQEIINKNRNGLEVVKALAQGGFTDVAQDMLNIQKAKLTGDYLHTSAIIVGDGQVLSAVNDVNDYAGPATGYRLQGERWEEIKNIPGALDPN 3etq A 1.9 BS01 CMP A 1 V564 M572 F580 G581 E582 I583 S584 R591 T592 A593 R632 I636 V122 M130 F138 G139 E140 I141 S142 R149 T150 A151 R190 I194 ? Kd=920+-240nM (19525958) O88703 19525958 1 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNNRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEISLLTRGRRTASVRADTYSRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRI 3etq B 1.9 BS01 CMP B 1 V564 M572 F580 G581 E582 I583 S584 R591 T592 R632 R635 V121 M128 F136 G137 E138 I139 S140 R147 T148 R188 R191 ? Kd=920+-240nM (19525958) O88703 19525958 1 SSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNNRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKNKEMKLSDGSYFGEISLLTRGRRTASVRADTYSRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDR 3klo A 2.802 BS01 C2E A 1 W131 T133 R134 W129 T131 R132 ? 0000166,0000976,0001216,0003677,0006355,0032993,0045893 Kd=3.18uM (20150502) Q9KKZ8 20150502 225 DENKLNVRMLSDVCMQSRLLKEALESKLPLALEITPFSELWLEENKPESRSIQMLVIDYSRISDDVLTDYSSFKHISCPDAKEVIINCPQDIEHKLLFKWNNLAGVFYIDDDMDTLIKGMSKILQDEMWLTRKLAQEYILHYRAGNSVVTSQMYAKLTKREQQIIKLLGSGASNIEIADKLFVSENTVKTHLHNVFKKINAKNRLQALIWAKNNIGI 3klo B 2.802 BS01 C2E B 1 W131 T133 R134 W128 T130 R131 ? 0000166,0000976,0001216,0003677,0006355,0032993,0045893 Kd=3.18uM (20150502) Q9KKZ8 20150502 225 ENKLNVRMLSDVCMQSRLLKEALESKLPLALEITPFSELWLEENKPESRSIQMLVIDYSRISDDVLTDYSSFKHISCPDAKEVIINCPQDIEHKLLFKWNNLAGVFYIDDDMDTLIKGMSKILQDEMWLTRKLAQEYILHYRAGNSVVTSQMYAKLTKREQQIIKLLGSGASNIEIADKLFVSENTVKTHLHNVFKKINAKNRLQALIWAKNNIGI 3klo C 2.802 BS01 C2E C 1 W131 T133 R134 W128 T130 R131 ? 0000166,0000976,0001216,0003677,0006355,0032993,0045893 Kd=3.18uM (20150502) Q9KKZ8 20150502 225 ENKLNVRMLSDVCMQSRLLKEALESKLPLALEITPFSELWLEENKPESRSIQMLVIDYSRISDDVLTDYSSFKHISCPDAKEVIINCPQDIEHKLLFKWNNLAGVFYIDDDMDTLIKGMSKILQDEMWLTRKLAQEYILHYRAGNSVVTSQMYAKLTKREQQIIKLLGSGASNIEIADKLFVSENTVKTHLHNVFKKINAKNRLQALIWAKNN 3klo D 2.802 BS01 C2E D 1 W131 T133 R134 W128 T130 R131 ? 0000166,0000976,0001216,0003677,0006355,0032993,0045893 Kd=3.18uM (20150502) Q9KKZ8 20150502 225 ENKLNVRMLSDVCMQSRLLKEALESKLPLALEITPFSELWLEENKPESRSIQMLVIDYSRISDDVLTDYSSFKHISCPDAKEVIINCPQDIEHKLLFKWNNLAGVFYIDDDMDTLIKGMSKILQDEMWLTRKLAQEYILHYRAGNSVVTHLHNVFKKINAKNRLQALIWAKNN 3ocp A 2.49 BS01 CMP A 1 L172 F181 G182 E183 L184 A185 R192 T193 A194 L81 F90 G91 E92 L93 A94 R101 T102 A103 2.7.11.12 Kd=27+-3.6nM (21526164) Kd=27nM -logKd/Ki=7.57, Kd=27nM Q13976 21526164 250 SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMR 3ocp B 2.49 BS01 CMP B 1 V165 L172 M175 F181 G182 L184 A185 R192 T193 A194 V74 L81 M84 F90 G91 L93 A94 R101 T102 A103 2.7.11.12 Kd=27+-3.6nM (21526164) Kd=27nM Q13976 21526164 250 SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRT 3od0 A 2.9 BS01 PCG A 1 L172 F181 G182 E183 L184 A185 R192 T193 L81 F90 G91 E92 L93 A94 R101 T102 2.7.11.12 Kd=12+-1.6nM (21526164) -logKd/Ki=7.92, Kd=12nM Q13976 21526164 250 SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMR 3od0 A 2.9 BS02 PCG B 1 L187 N189 L96 N98 2.7.11.12 Kd=12+-1.6nM (21526164) -logKd/Ki=7.92, Kd=12nM Q13976 21526164 250 SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMR 3od0 B 2.9 BS01 PCG B 1 L172 F181 G182 E183 L184 A185 R192 T193 A194 L81 F90 G91 E92 L93 A94 R101 T102 A103 2.7.11.12 Kd=12+-1.6nM (21526164) -logKd/Ki=7.92, Kd=12nM Q13976 21526164 250 SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMR 3ogj A 2.751 BS01 CMP A 1 L172 F181 G182 E183 L184 A185 R192 T193 L81 F90 G91 E92 L93 A94 R101 T102 2.7.11.12 Kd=27+-3.6nM (21526164) Q13976 21526164 250 SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRT 3ogj B 2.751 BS01 CMP B 1 L172 C173 M175 F181 G182 E183 L184 A185 R192 T193 A194 L81 C82 M84 F90 G91 E92 L93 A94 R101 T102 A103 2.7.11.12 Kd=27+-3.6nM (21526164) Q13976 21526164 250 SHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMR 3pjt A 2.5154 BS01 C2E A 1 Q431 K446 L448 S449 R450 A461 G462 L465 M481 N499 Q560 R561 R618 E620 G638 Q639 Q23 K38 L40 S41 R42 A53 G54 L57 M73 N91 Q152 R153 R210 E212 G230 Q231 ? Kd=13.1uM (21304926) -logKd/Ki=4.88, Kd=13.1uM Q3KK31 21304926 2256 DHHAWHRLLDQALNQRRFELFFQPVVAAQDTQLVLHYKVLSRLLDEQGQTIPAGRFLPWLERFGWTARLDRLMLERVLEQMAGHEESLALNLSSATLADPQALNKVFEILRAHSNLGARLTLEIGEEQLPEQAVLEQLTRRLRELGFSLSLQRFGGRFSMIGNLARLGLAYLKIDGSYIRAIDQESDKRLFIEAIQRAAHSIDLPLIAERVETEGELSVIREMGLYGVQGQLFGEPKPWG 3pjt B 2.5154 BS01 C2E B 1 Q431 K446 L448 S449 R450 L465 M481 N499 Q560 R561 R618 E620 G638 Q639 Q23 K38 L40 S41 R42 L57 M73 N91 Q152 R153 R210 E212 G230 Q231 ? Kd=13.1uM (21304926) Q3KK31 21304926 2256 DHHAWHRLLDQALNQRRFELFFQPVVAAQDTQLVLHYKVLSRLLDEQGQTIPAGRFLPWLERFGWTARLDRLMLERVLEQMAGHEESLALNLSSATLADPQALNKVFEILRAHSNLGARLTLEIGEEQLPEQAVLEQLTRRLRELGFSLSLQRFGGRFSMIGNLARLGLAYLKIDGSYIRAIDQESDKRLFIEAIQRAAHSIDLPLIAERVETEGELSVIREMGLYGVQGQLFGEPKPWG 3q6k A 2.52 BS01 SRO A 1 T29 Q91 F223 T327 N342 F344 T29 Q91 F223 T327 N342 F344 ? 0005576 Kd=4.3nM (21795673) -logKd/Ki=8.37, Kd=4.3nM Q5WPU9 21795673 383 ADTQGYKWKQLLYNNVTPGSYNPDNMISTAFAYDAEGEKLFLAVPRKLPRVPYTLAEVDTKNSLGVKGKHSPLLNKFSGHKTGKELTSIYQPVIDDCRRLWVVDIGSVEYRSRGAKDYPSHRPAIVAYDLKQPNYPEVVRYYFPTRLVEKPTYFGGFAVDVANPKGDCSETFVYITNFLRGALFIYDHKKQDSWNVTHPTFKAERPTKFDYGGKEYEFKAGIFGITLGDRDSEGNRPAYYLAGSAIKVYSVNTKELKQKGGKLNPELLGNRGKYNDAIALAYDPKTKVIFFAEANTKQVSCWNTQKMPLRMKNTDVVYTSSRFVFGTDISVDSKGGLWFMSNGFPPIRKSEKFKYDFPRYRLMRIMDTQEAIAGTACDMN 3q6k B 2.52 BS01 SRO B 1 T29 Y90 T327 N342 F344 T29 Y90 T327 N342 F344 ? 0005576 Kd=4.3nM (21795673) Q5WPU9 21795673 383 ADTQGYKWKQLLYNNVTPGSYNPDNMISTAFAYDAEGEKLFLAVPRKLPRVPYTLAEVDTKNSLGVKGKHSPLLNKFSGHKTGKELTSIYQPVIDDCRRLWVVDIGSVEYRSRGAKDYPSHRPAIVAYDLKQPNYPEVVRYYFPTRLVEKPTYFGGFAVDVANPKGDCSETFVYITNFLRGALFIYDHKKQDSWNVTHPTFKAERPTKFDYGGKEYEFKAGIFGITLGDRDSEGNRPAYYLAGSAIKVYSVNTKELKQKGGKLNPELLGNRGKYNDAIALAYDPKTKVIFFAEANTKQVSCWNTQKMPLRMKNTDVVYTSSRFVFGTDISVDSKGGLWFMSNGFPPIRKSEKFKYDFPRYRLMRIMDTQEAIAGTACDMNA 3qyy A 1.9 BS01 C2E A 1 L177 K178 N181 H186 G189 D190 R212 G215 D216 L44 K45 N48 H53 G56 D57 R79 G82 D83 2.7.7.65 Ki=6.54uM (22120736) Kd=8.26uM -logKd/Ki=5.08, Kd=8.26uM Q8P559 22120736 487 HALFDPLTEALNRRGCEQAMRDSVTAAQREGWPFVLFVLDMDNLKPINDRFGHLAGDRVLVRLVESAYGWLGAQDWIGRWGGDEFLIGVHASEDEATLKLNQWLSMLEREAPLHVSAGSAVCEVGIDATELYRRADAAMYRAKFSGGRRLVRD 3qyy A 1.9 BS02 MG A 1 D173 D216 D40 D83 2.7.7.65 Ki=6.54uM (22120736) Q8P559 22120736 505 HALFDPLTEALNRRGCEQAMRDSVTAAQREGWPFVLFVLDMDNLKPINDRFGHLAGDRVLVRLVESAYGWLGAQDWIGRWGGDEFLIGVHASEDEATLKLNQWLSMLEREAPLHVSAGSAVCEVGIDATELYRRADAAMYRAKFSGGRRLVRD 3qyy A 1.9 BS03 C2E B 1 R146 W213 G214 G215 E217 R13 W80 G81 G82 E84 2.7.7.65 Ki=6.54uM (22120736) Kd=8.26uM -logKd/Ki=5.08, Kd=8.26uM Q8P559 22120736 486 HALFDPLTEALNRRGCEQAMRDSVTAAQREGWPFVLFVLDMDNLKPINDRFGHLAGDRVLVRLVESAYGWLGAQDWIGRWGGDEFLIGVHASEDEATLKLNQWLSMLEREAPLHVSAGSAVCEVGIDATELYRRADAAMYRAKFSGGRRLVRD 3qyy B 1.9 BS01 C2E A 1 R146 W213 G214 G215 E217 R17 W84 G85 G86 E88 2.7.7.65 Ki=6.54uM (22120736) Kd=8.26uM -logKd/Ki=5.08, Kd=8.26uM Q8P559 22120736 487 DLKRHALFDPLTEALNRRGCEQAMRDSVTAAQREGWPFVLFVLDMDNLKPINDRFGHLAGDRVLVRLVESAYGWLGAQDWIGRWGGDEFLIGVHASEDEATLKLNQWLSMLEEAPLHVSAGSAVCEVGIDATELYRRADAAMYRAKFSGGRRLVRD 3qyy B 1.9 BS02 C2E B 1 L177 K178 N181 H186 G189 D190 L193 R212 G215 D216 L48 K49 N52 H57 G60 D61 L64 R83 G86 D87 2.7.7.65 Ki=6.54uM (22120736) Kd=8.26uM -logKd/Ki=5.08, Kd=8.26uM Q8P559 22120736 486 DLKRHALFDPLTEALNRRGCEQAMRDSVTAAQREGWPFVLFVLDMDNLKPINDRFGHLAGDRVLVRLVESAYGWLGAQDWIGRWGGDEFLIGVHASEDEATLKLNQWLSMLEEAPLHVSAGSAVCEVGIDATELYRRADAAMYRAKFSGGRRLVRD 3qyy B 1.9 BS03 MG B 1 D173 D216 D44 D87 2.7.7.65 Ki=6.54uM (22120736) Q8P559 22120736 506 DLKRHALFDPLTEALNRRGCEQAMRDSVTAAQREGWPFVLFVLDMDNLKPINDRFGHLAGDRVLVRLVESAYGWLGAQDWIGRWGGDEFLIGVHASEDEATLKLNQWLSMLEEAPLHVSAGSAVCEVGIDATELYRRADAAMYRAKFSGGRRLVRD 3u0z A 2.9 BS01 CMP A 1 L521 F527 G528 E529 I530 C531 R538 T539 R579 R582 L132 F138 G139 E140 I141 C142 R149 T150 R190 R193 ? Kd=39.7nM (22006928) O88704 22006928 646 DSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNS 3u0z B 2.9 BS01 CMP B 1 L521 F527 G528 E529 I530 C531 R538 T539 A540 R579 L132 F138 G139 E140 I141 C142 R149 T150 A151 R190 ? Kd=39.7nM (22006928) O88704 22006928 646 DSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNS 3u10 A 2.3 BS01 CMP A 1 V591 M599 F607 G608 E609 I610 C611 R618 T619 A620 R659 I663 V122 M130 F138 G139 E140 I141 C142 R149 T150 A151 R190 I194 ? Kd=82.0nM (22006928) -logKd/Ki=5.44, Kd=3.6uM Q9UL51 22006928 701 DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILL 3u11 A 2.5 BS01 CMP A 1 V642 T650 F658 G659 E660 I661 C662 R669 T670 R710 V122 T130 F138 G139 E140 I141 C142 R149 T150 R190 ? Kd=39.2nM (22006928) Q9Y3Q4 22006928 846 DSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKN 3u11 B 2.5 BS01 CMP B 1 V642 F658 G659 E660 I661 C662 R669 T670 R710 I714 V122 F138 G139 E140 I141 C142 R149 T150 R190 I194 ? Kd=39.2nM (22006928) Q9Y3Q4 22006928 846 DSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILL 4dn0 A 2.3 BS01 C2E A 1 R161 R367 D370 G395 G398 Y399 R402 R4 R191 D194 G219 G222 Y223 R226 ? Kd=1.9uM (22605337) Kd=1.9uM -logKd/Ki=5.72, Kd=1.9uM A0A0H2ZD98 22605337 501 QSLRSSLLGLRQLLRELPGDEAPLDALAETVLALLAQYGSLRIAGLYRVRHDRTPEPQPLATLGEMPVLDADDLLVRTCLERGELVSVRQELALQVCVPLVDTDGRILALLAVEQMPFFVFNERTFSLLAILAGHIADLLQDIDAQRFSQYLKRSLLDARDHGLPACLYAFELTDARYGEEVQRLLEGSQRGLDVQLRLRNDEGRRVLLVLLPLTSAEGSQGYLQRLRILFAERFGQARELESLGVRIRQYELDAGNDRQALGHFLFNECGLNDQQVAV 4dn0 A 2.3 BS02 C2E A 2 R161 L165 Q366 R367 G368 R402 R4 L8 Q190 R191 G192 R226 ? Kd=1.9uM (22605337) Kd=1.9uM -logKd/Ki=5.72, Kd=1.9uM A0A0H2ZD98 22605337 502 QSLRSSLLGLRQLLRELPGDEAPLDALAETVLALLAQYGSLRIAGLYRVRHDRTPEPQPLATLGEMPVLDADDLLVRTCLERGELVSVRQELALQVCVPLVDTDGRILALLAVEQMPFFVFNERTFSLLAILAGHIADLLQDIDAQRFSQYLKRSLLDARDHGLPACLYAFELTDARYGEEVQRLLEGSQRGLDVQLRLRNDEGRRVLLVLLPLTSAEGSQGYLQRLRILFAERFGQARELESLGVRIRQYELDAGNDRQALGHFLFNECGLNDQQVAV 4ef4 A 2.147 BS01 C2E A 1 Y167 T263 P264 Y16 T103 P104 ? 0002218,0032481 Kd=4.42uM (22579474) Kd=4.42uM -logKd/Ki=5.35, Kd=4.42uM EC50=4500nM, Kd=1210nM Q86WV6 22579474 401 NFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPFSLSQEVLRHLRQEEKEEVTV 4ef4 A 2.147 BS02 CA A 1 D205 E316 D54 E156 ? 0002218,0032481 Kd=4.42uM (22579474) Q86WV6 22579474 402 NFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPFSLSQEVLRHLRQEEKEEVTV 4ef4 B 2.147 BS01 C2E A 1 Y167 T263 P264 Y16 T100 P101 ? 0002218,0032481 Kd=4.42uM (22579474) -logKd/Ki=5.35, Kd=4.42uM EC50=4500nM, Kd=1210nM Q86WV6 22579474 401 NFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPASFSLSQEVLRHLRQEEKEEVTV 4emt A 1.5 BS01 C2E A 1 Y163 Y167 R238 T263 P264 Y10 Y14 R76 T101 P102 ? 0002218,0032481 Kd=5uM (22728658) Kd=4.63uM -logKd/Ki=5.30, Kd~5uM EC50=4500nM, Kd=1210nM Q86WV6 22728658 401 SVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEE 4emt B 1.5 BS01 C2E A 1 Y167 T263 P264 Y14 T101 P102 ? 0002218,0032481 Kd=5uM (22728658) -logKd/Ki=5.30, Kd~5uM EC50=4500nM, Kd=1210nM Q86WV6 22728658 401 SVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEE 4emt B 1.5 BS02 CA B 1 A318 D320 A156 D158 ? 0002218,0032481 Kd=5uM (22728658) Q86WV6 22728658 401 SVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEE 4etz A 2.05 BS01 C2E A 1 Q158 R367 D370 G395 G398 Y399 R402 Q1 R198 D201 G226 G229 Y230 R233 ? Kd=0.5uM (22810222) Kd~0.5uM -logKd/Ki=6.30, Kd=0.5uM Q9HZE7 22810222 501 QSLRSSLLGLRQLLRELPGDEAPLDALAETVLALLAQYGSLRIAGLYRVRYDRTPEPQPLATLGEMPALDADDLLVRTCLERGELVSVRQALQVCVPLVDTDGRILALLAVEQMPFFVFNERTFSLLAILAGHIADLLQSDRRALQLADIDAQRFSQYLKRSLLDARDHGLPACLYAFELTDARYGEEVQRLLEGSQRGLDVQLRLRNDEGRRVLLVLLPLTSAEGSQGYLQRLRILFAERFGQARELESLGVRIRQYELDAGNDRQALGHFLFNECGLNDQQVA 4etz B 2.05 BS01 C2E B 1 R367 D370 G395 G398 Y399 R402 R202 D205 G230 G233 Y234 R237 ? Kd=0.5uM (22810222) Kd~0.5uM Q9HZE7 22810222 501 QSLRSSLLGLRQLLRELPGDEAPLDALAETVLALLAQYGSLRIAGLYRVRYDRTPEPQPLATLGEMPALDADDLLVRTCLERGELVSVRQELLEALQVCVPLVDTDGRILALLAVEQMPFFVFNERTFSLLAILAGHIADLLQSDRRALQLADIDAQRFSQYLKRSLLDARDHGLPACLYAFELTDARYGEEVQRLLEGSQRGLDVQLRLRNDEGRRVLLVLLPLTSAEGSQGYLQRLRILFAERFGQARELESLGVRIRQYELDAGNDRQALGHFLFNECGLNDQQVA 4eu0 A 1.7 BS01 C2E A 1 R367 D370 G395 G398 Y399 R402 R197 D200 G225 G228 Y229 R232 ? Kd=0.5uM (22810222) Kd=0.4uM -logKd/Ki=6.40, Kd=0.4uM Q9HZE7 22810222 501 QSLRSSLLGLRQLLRELPGDEAPLDALAETVLALLAQYGSLRIAGLYRVRYDRTPEPQPLATLGEMPALDADDLLVRTCLERGELVSVRQAAVCVPLVDTDGRILALLAVEQMPFFVFNERTFSLLAILAGHIADLLQSDRRALQLADIDAQRFSQYLKRSLLDARDHGLPACLYAFELTDARYGEEVQRLLEGSQRGLDVQLRLRNDEGRRVLLVLLPLTSAEGSQGYLQRLRILFAERFGQARELESLGVRIRQYELDAGNDRQALGHFLFNECGLNDQQVAI 4euv A 2.0 BS01 C2E A 1 R367 D370 L388 G395 G398 Y399 R402 R199 D202 L220 G227 G230 Y231 R234 ? Kd=0.5uM (22810222) Kd~0.5uM -logKd/Ki=6.30, Kd=0.5uM Q9HZE7 22810222 501 QSLRSSLLGLRQLLRELPGDEAPLDALAETVLALLAQYGSLRIAGLYRVRYDRTPEPQPLATLGEMPALDADDLLVRTCLERGELVSVRQELAAVCVPLVDTDGRILALLAVEQMPFFVFNERTFSLLAILAGHIADLLQSDRRALQLADIDAQRFSQYLKRSLLDARDHGLPACLYAFELTDARYGEEVQRLLEGSQRGLDVQLRLRNDEGRRVLLVLLPLTSAEGSQGYLQRLRILFAERFGQARELESLGVRIRQYELDAGNDRQALGHFLFNECGLNDQQVA 4f5y A 2.396 BS01 CA A 1 D205 E316 D55 E166 ? 0002218,0032481 Kd=3.7uM (22728660) Q86WV6 22728660 401 GNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTV 4f5y A 2.396 BS02 C2E A 1 S162 Y167 R238 V239 T263 S12 Y17 R88 V89 T113 ? 0002218,0032481 Kd=3.7uM (22728660) -logKd/Ki=5.43, Kd=3.70uM EC50=4500nM, Kd=1210nM Q86WV6 22728660 402 GNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTV 4f5y B 2.396 BS01 C2E A 1 S162 Y167 T263 P264 S12 Y17 T113 P114 ? 0002218,0032481 Kd=3.7uM (22728660) -logKd/Ki=5.43, Kd=3.70uM EC50=4500nM, Kd=1210nM Q86WV6 22728660 402 GNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTV 4f5y B 2.396 BS02 CA B 1 D205 E316 D55 E166 ? 0002218,0032481 Kd=3.7uM (22728660) Q86WV6 22728660 500 GNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTV 4f9g A 2.95 BS01 C2E A 1 Y167 T263 P264 Y14 T97 P98 ? 0002218,0032481 Km=2.4+-0.5mM (22705373) -logKd/Ki=5.62, Kd=2.4uM EC50=4500nM, Kd=1210nM Q86WV6 22705373 401 NVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPNNCRLIAYQEPSFSLSQEVLRHLRQEEKEEVTV 4f9g C 2.95 BS01 C2E A 1 Y167 T263 P264 Y14 T97 P98 ? 0002218,0032481 Km=2.4+-0.5mM (22705373) -logKd/Ki=5.62, Kd=2.4uM EC50=4500nM, Kd=1210nM Q86WV6 22705373 401 NVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPNNCRLIAYQEPFSLSQEVLRHLRQEEKEEVTV