Structure of PDB 8hki Chain z

Receptor sequence
>8hkiz (length=316) Species: 9606 (Homo sapiens) [Search protein sequence]
TLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIK
LTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQ
ADLYISEGLHPRIITEGFEAAKEKALQFLEEVKVSREMDRETLIDVARTS
LRTKVHAELKHKSETDTGPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPG
AGAVEVAMAEALIKHKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQ
ETLVKIQAEHSESGQLVGVDLNTGEPMVAAEVGVWDNYCVKKQLLHSCTV
IATNILLVDEIMRAGM
3D structure
PDB8hki Pathway and mechanism of tubulin folding mediated by TRiC/CCT conjugated with its ATPase cycle revealed by cryo-EM
Chainz
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP z D90 G91 T154 R157 T158 G410 A411 D496 D85 G86 T149 R152 T153 G200 A201 D286
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0044183 protein folding chaperone
GO:0051082 unfolded protein binding
GO:0071987 WD40-repeat domain binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051086 chaperone mediated protein folding independent of cofactor
GO:0061077 chaperone-mediated protein folding
GO:1904851 positive regulation of establishment of protein localization to telomere
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0070062 extracellular exosome

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Cellular Component
External links
PDB RCSB:8hki, PDBe:8hki, PDBj:8hki
PDBsum8hki
PubMed
UniProtP40227|TCPZ_HUMAN T-complex protein 1 subunit zeta (Gene Name=CCT6A)

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