Structure of PDB 8cah Chain z

Receptor sequence

>8cahz (length=120) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence]

THPLFNAETKREYQDLRKALTAAITPMNKKSPLNYSSSLAIDLIRDVAKP
MSIESIRQTVATLNVLIKDKEREERQARLARVRGGTATGGAGKKKVKGKT
NLGGAFKKDQDFDLDGPDDF

3D structure

PDB

8cah Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.

Chain

Resolution

3.0 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	z	R148 R212 R215 T225 G227 G229 K230 K231 K234 T237 L239 K244 K245	R11 R75 R78 T88 G90 G92 K93 K94 K97 T100 L102 K107 K108

Gene Ontology

	Molecular Function
GO:0003743	translation initiation factor activity
GO:0005515	protein binding

	Biological Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001732	formation of cytoplasmic translation initiation complex
GO:0002181	cytoplasmic translation
GO:0002183	cytoplasmic translational initiation
GO:0006412	translation
GO:0006413	translational initiation

	Cellular Component
GO:0005737	cytoplasm
GO:0005852	eukaryotic translation initiation factor 3 complex
GO:0010494	cytoplasmic stress granule
GO:0016282	eukaryotic 43S preinitiation complex
GO:0033290	eukaryotic 48S preinitiation complex

External links

PDB	RCSB:8cah, PDBe:8cah, PDBj:8cah
PDBsum	8cah
PubMed	37169754
UniProt	Q05775\|EIF3J_YEAST Eukaryotic translation initiation factor 3 subunit J (Gene Name=HCR1)