Structure of PDB 8rg0 Chain y

Receptor sequence

>8rg0y (length=543) Species: 9606 (Homo sapiens) [Search protein sequence]

MFAKGTEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLVQIAAENNL
GEGVIVKIKFNIIASLYDYNPNLATYMKPEMWGKCLDCINELMDILFANP
NIFVGENILEESENLHNADQPLRVRGCILTLVERMDEEFTKIMQNTDPHS
QEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDY
KAHQRQNEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRW
YQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNA
LLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELL
ECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPES
MREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRK
IQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELM
ASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFD

3D structure

PDB

8rg0 Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining

Chain

Resolution

3.4 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	y	L650 R653 H716 R723	L318 R321 H384 R391
BS02	rna	y	K342 K343	K26 K27

External links

PDB	RCSB:8rg0, PDBe:8rg0, PDBj:8rg0
PDBsum	8rg0
PubMed
UniProt	Q99613\|EIF3C_HUMAN Eukaryotic translation initiation factor 3 subunit C (Gene Name=EIF3C)

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