Structure of PDB 7syw Chain x

Receptor sequence

>7sywx (length=627) Species: 9986 (Oryctolagus cuniculus)

DSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPVICVLGHVDTG
KTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENV
RIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINL
LKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKA
IIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQ
TMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGV
EGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLA
GLPLLVAYKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEA
LLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIER
DAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCK
MKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEV
NHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDA
LKDWFRDEMQKSDWQLIVELKKVFEII

3D structure

• PDB: 7syw Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
• Chain: x
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	x	G866 R900 K914 N915 K919 H1012 K1014 R1041	G275 R309 K323 N324 K328 H421 K423 R450
BS02	rna	x	F1100 S1102 R1103 E1140 N1142 H1143 C1156 M1169 R1172	F509 S511 R512 E549 N551 H552 C565 M578 R581
BS03	GTP	x	T640 G641 K642 T643 K644 Q655 K755 A823	T49 G50 K51 T52 K53 Q64 K164 A232
BS04	MG	x	T643 T663	T52 T72

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding

External links

• PDB: RCSB:7syw, PDBe:7syw, PDBj:7syw
• PDBsum: 7syw
• PubMed: 35822879
• UniProt: G1TRL5