Structure of PDB 7obq Chain x

Receptor sequence
>7obqx (length=393) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
ATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLEEMASGL
NKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCS
KLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPV
IIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVY
VMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSP
IIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLEALIEKLKHGQFTLRD
MYEQFQNIMKMGPFSQILGNEQESMARLKKLMTIMDSMNDQELDSTDGAK
VFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGI
3D structure
PDB7obq Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle.
Chainx
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.4: signal-recognition-particle GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna x S381 M382 N383 D384 Q399 G401 R402 R405 G409 S337 M338 N339 D340 Q355 G357 R358 R361 G365
BS02 GNP x G113 K114 T115 T116 K120 Q147 G193 K249 G276 E277 G94 K95 T96 T97 K101 Q128 G174 K230 G257 E258
BS03 MG x K114 T115 K95 T96
BS04 GNP x Q110 R141 Q91 R122
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0008312 7S RNA binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019003 GDP binding
GO:0030942 endoplasmic reticulum signal peptide binding
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0030593 neutrophil chemotaxis
GO:0030851 granulocyte differentiation
GO:0031017 exocrine pancreas development
GO:0045047 protein targeting to ER
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0048500 signal recognition particle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7obq, PDBe:7obq, PDBj:7obq
PDBsum7obq
PubMed34260909
UniProtP61010|SRP54_CANLF Signal recognition particle subunit SRP54 (Gene Name=SRP54)

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