Structure of PDB 8r6c Chain w

Receptor sequence

>8r6cw (length=77) Species: 679895 (Escherichia coli BW25113)

SRVCQVTGKRPVTGNNRSHALNATKRRFLPNLHSHRFWVESEKRFVTLRV
SAKGMRVIDKKGIDTVLAELRARGEKY

3D structure

• PDB: 8r6c Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis.
• Chain: w
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	w	H20 A21	H19 A20
BS02	rna	w	S2 R3 K10 V13 T14 G15 N16 R18 S19 H20 A21 L22 N23 T25 K26 R27 R28 F29 L30 P31 N32 H34 H36 R37 R50 A53 K54 M56 R57 K61 K62	S1 R2 K9 V12 T13 G14 N15 R17 S18 H19 A20 L21 N22 T24 K25 R26 R27 F28 L29 P30 N31 H33 H35 R36 R49 A52 K53 M55 R56 K60 K61

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8r6c, PDBe:8r6c, PDBj:8r6c
• PDBsum: 8r6c
• PubMed: 38826346
• UniProt: P0A7M2|RL28_ECOLI Large ribosomal subunit protein bL28 (Gene Name=rpmB)