Structure of PDB 7b12 Chain w

Receptor sequence
>7b12w (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
TTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAA
DAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIV
GGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEA
AQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSG
RYHFVPGTTAVLTQTVKPLT
3D structure
PDB7b12 Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i).
Chainw
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SKN w T1 R19 A20 T21 C31 K33 H35 G47 A49 E53 T1 R19 A20 T21 C31 K33 H35 G47 A49 E53
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7b12, PDBe:7b12, PDBj:7b12
PDBsum7b12
PubMed34228444
UniProtP40306|PSB10_HUMAN Proteasome subunit beta type-10 (Gene Name=PSMB10)

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