Structure of PDB 8r8m Chain v

Receptor sequence

>8r8mv (length=78) Species: 679895 (Escherichia coli BW25113)

GSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRDH
TLFAKADGKVKFEVKGPKNRKFISIEAE

3D structure

• PDB: 8r8m Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis.
• Chain: v
• Resolution: 2.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	v	G73 P74 N76	G66 P67 N69
BS02	rna	v	G8 S9 R11 N12 R14 D15 S16 E17 A18 K19 R20 K24 R25 F26 G27 E29 A33 G34 S35 I36 R41 G42 T43 H46 G54 R55 D56 H57 T58 F60 F69 K75 R77 K78	G1 S2 R4 N5 R7 D8 S9 E10 A11 K12 R13 K17 R18 F19 G20 E22 A26 G27 S28 I29 R34 G35 T36 H39 G47 R48 D49 H50 T51 F53 F62 K68 R70 K71

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0043022 ribosome binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0001558 regulation of cell growth
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042256 cytosolic ribosome assembly
• GO:0090070 positive regulation of ribosome biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8r8m, PDBe:8r8m, PDBj:8r8m
• PDBsum: 8r8m
• PubMed: 38826346
• UniProt: P0A7L8|RL27_ECOLI Large ribosomal subunit protein bL27 (Gene Name=rpmA)