Structure of PDB 8r6c Chain v

Receptor sequence

>8r6cv (length=83) Species: 679895 (Escherichia coli BW25113)

HKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVG
CGRDHTLFAKADGKVKFEVKGPKNRKFISIEAE

3D structure

• PDB: 8r6c Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis.
• Chain: v
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	v	H3 K5 A6	H1 K3 A4
BS02	rna	v	H3 K4 S9 T10 R11 N12 R14 D15 S16 E17 A18 K19 R20 K24 F26 G27 E29 L32 A33 G34 S35 I36 R41 G42 T43 H46 G54 R55 D56 H57 T58 F60 F69 K75 R77 K78	H1 K2 S7 T8 R9 N10 R12 D13 S14 E15 A16 K17 R18 K22 F24 G25 E27 L30 A31 G32 S33 I34 R39 G40 T41 H44 G52 R53 D54 H55 T56 F58 F67 K73 R75 K76
BS03	rna	v	G73 P74 N76	G71 P72 N74

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0043022 ribosome binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0001558 regulation of cell growth
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042256 cytosolic ribosome assembly
• GO:0090070 positive regulation of ribosome biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8r6c, PDBe:8r6c, PDBj:8r6c
• PDBsum: 8r6c
• PubMed: 38826346
• UniProt: P0A7L8|RL27_ECOLI Large ribosomal subunit protein bL27 (Gene Name=rpmA)