Structure of PDB 8i0w Chain v

Receptor sequence
>8i0wv (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]
SDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYV
HKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTS
KIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI
3D structure
PDB8i0w Molecular basis for the activation of human spliceosome
Chainv
Resolution3.4 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide v H15 K18 F19 Y42 K43 R84 V85 H11 K14 F15 Y38 K39 R80 V81
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0006417 regulation of translation
GO:0008380 RNA splicing
GO:0050684 regulation of mRNA processing
GO:0051028 mRNA transport
GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
GO:0071013 catalytic step 2 spliceosome
GO:1990501 exon-exon junction subcomplex mago-y14

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0w, PDBe:8i0w, PDBj:8i0w
PDBsum8i0w
PubMed39068178
UniProtP61326|MGN_HUMAN Protein mago nashi homolog (Gene Name=MAGOH)

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