Structure of PDB 8aaf Chain v

Receptor sequence

>8aafv (length=142) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

SATYPMQCSALRKNGFVVIKSRPCKIVDMSTSKTGKHGHAKVHLVAIDIF
TGKKLEDLSPSTHNMEVPVVKRNEYQLLDIDDGFLSLMNMDGDTKDDVKA
PEGELGDSLQTAFDEGKDLMVTIISAMGEEAAISFKEAARTD

3D structure

PDB

8aaf Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.

Chain

Resolution

2.5 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	v	T49 G50 X51 H52 H54 K56 K69 E71 L73	T34 G35 X36 H37 H39 K41 K54 E56 L58

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0003746	translation elongation factor activity
GO:0005515	protein binding
GO:0043022	ribosome binding

	Biological Process
GO:0002182	cytoplasmic translational elongation
GO:0002184	cytoplasmic translational termination
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006452	translational frameshifting
GO:0045901	positive regulation of translational elongation
GO:0045905	positive regulation of translational termination
GO:0045948	positive regulation of translational initiation
GO:0072344	rescue of stalled ribosome
GO:0097622	cytoplasmic translational elongation through polyproline stretches
GO:0140708	CAT tailing
GO:1903272	positive regulation of cytoplasmic translational elongation through polyproline stretches

	Cellular Component
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm

External links

PDB	RCSB:8aaf, PDBe:8aaf, PDBj:8aaf
PDBsum	8aaf
PubMed	36804914
UniProt	P23301\|IF5A1_YEAST Eukaryotic translation initiation factor 5A-1 (Gene Name=HYP2)