Structure of PDB 7nfx Chain v

Receptor sequence
>7nfxv (length=186) Species: 9606 (Homo sapiens) [Search protein sequence]
RAVLLVGLCDSGKTLLFVRLLTGLYRDTQTSITDSCAVYRVNNNRGNSLT
LIDLPGHESLRLQFLERFKSSARAIVFVVDSAAFQREVKDVAEFLYQVLI
DSMGLKNTPSFLIACNKQDIAMAKSAKLIQQQLEKELNTLRVTGKEFEFS
QLPLKVEFLECSAKGGRGDVGSADIQDLEKWLAKIA
3D structure
PDB7nfx Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.
Chainv
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG v T78 S95 T14 S31
BS02 GTP v C73 D74 G76 K77 T78 L79 T92 S95 G120 N180 K181 D183 S247 A248 K249 C9 D10 G12 K13 T14 L15 T28 S31 G56 N116 K117 D119 S162 A163 K164
Gene Ontology
Biological Process
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0045047 protein targeting to ER
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005785 signal recognition particle receptor complex
GO:0005789 endoplasmic reticulum membrane
GO:0005881 cytoplasmic microtubule
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7nfx, PDBe:7nfx, PDBj:7nfx
PDBsum7nfx
PubMed34020957
UniProtQ9Y5M8|SRPRB_HUMAN Signal recognition particle receptor subunit beta (Gene Name=SRPRB)

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