Structure of PDB 6vlz Chain v

Receptor sequence

>6vlzv (length=712) Species: 9606 (Homo sapiens)

VIPNEKIRNIGISAHIDSGKTTLTERVLYYTGRIAKMHEVKGKDGVGAVM
DSMELERQRGITIQSAATYTMWKDVNINIIDTPGHVDFTIEVERALRVLD
GAVLVLCAVGGVQCQTMTVNRQMKRYNVPFLTFINKLDRMGSNPARALQQ
MRSKLNHNAAFMQIPMGLEGNFKGIVDLIEERAIYFDGDFGQIVRYGEIP
AELRAAATDHRQELIECVANSDEQLGEMFLEEKIPSISDLKLAIRRATLK
RSFTPVFLGSALKNKGVQPLLDAVLEYLPNPSEVQNYAILNKEDDSKEKT
KILMNSSRDNSHPFVGLAFKLEVGRFGQLTYVRSYQGELKKGDTIYNTRT
RKKVRLQRLARMHADMMEDVEEVYAGDICALFGIDCASGDTFTDKANSGL
SMESIHVPDPVISIAMKPSNKNDLEKFSKGIGRFTREDPTFKVYFDTENK
ETVISGMGELHLEIYAQRLEREYGCPCITGKPKVAFRETITAPVPFDFTH
KKQSGGAGQYGKVIGVLEPLDPEDYTKLEFSDETFGSNIPKQFVPAVEKG
FLDACEKGPLSGHKLSGLRFVLQDGAHHMVDSNEISFIRAGEGALKQALA
NATLCILEPIMAVEVVAPNEFQGQVIAGINRRHGVITGQDGVEDYFTLYA
DVPLNDMFGYSTELRSCTEGKGEYTMEYSRYQPCLPSTQEDVINKYLEAT
GQLPVKKGKAKN

3D structure

• PDB: 6vlz Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation.
• Chain: v
• Resolution: 2.97 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	v	R364 F365 K380 Q396 R397 K468	R325 F326 K341 Q357 R358 K429
BS02	rna	v	I55 K80 H124 V125 R178 L499 R628 Q661 I665 A666 N669 R670 I675 T676 G677 Q678 T701 R704 E708	I16 K41 H85 V86 R139 L460 R589 Q622 I626 A627 N630 R631 I636 T637 G638 Q639 T662 R665 E669
BS03	MG	v	T60 T101	T21 T62

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation
• GO:0070125 mitochondrial translational elongation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix

External links

• PDB: RCSB:6vlz, PDBe:6vlz, PDBj:6vlz
• PDBsum: 6vlz
• PubMed: 32737313
• UniProt: Q96RP9|EFGM_HUMAN Elongation factor G, mitochondrial (Gene Name=GFM1)