Structure of PDB 5z57 Chain v

Receptor sequence
>5z57v (length=165) Species: 9606 (Homo sapiens) [Search protein sequence]
SSSESNRDRRERLRQLALPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQG
KKHQTNLARRAAKEAKRPGYKVTKQRDSEMGQQSDYPEIAMPRHRFMSAY
EQRPDRRWQYLLMAAEPYETIAFKVPSREIDKAEGKFWTHWNRETKQFFL
QFHFKMEKPPAPPSL
3D structure
PDB5z57 Structure of the human activated spliceosome in three conformational states.
Chainv
Resolution6.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna v S19 T61 L62 H72 K77 S2 T36 L37 H47 K52
BS02 ZN v C56 C59 H72 H78 C31 C34 H47 H53
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010976 positive regulation of neuron projection development
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0016607 nuclear speck
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:5z57, PDBe:5z57, PDBj:5z57
PDBsum5z57
PubMed29360106
UniProtQ15428|SF3A2_HUMAN Splicing factor 3A subunit 2 (Gene Name=SF3A2)

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