Structure of PDB 8pj5 Chain u

Receptor sequence

>8pj5u (length=706) Species: 9606 (Homo sapiens) [Search protein sequence]

MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPI
MLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKMAEEK
TEAAKEESQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWV
KFLWESYRQCLDLLRNNSRVERLYHDIAQQAFKFCLQYTRKAEFRKLCDN
LRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAF
KAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLY
HLSREMRKNLTQDEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVE
KQRRLATLLGLQAPPTRIGLINDMVRFNVLQYVVPEVKDLYNWLEVEFNP
LKLCERVTKVLNWVREQPEKEPELQQYVPQLQNNTILRLLQQVSQIYQSI
EFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYA
TREDAPIGPHLQSMPSEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQH
QLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAE
LQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGA
KAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFER
AKRLEE

3D structure

PDB

8pj5 Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining

Chain

Resolution

2.9 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	u	M1 Y4 K38 K39 Y72 R143 R158 R195 K196	M1 Y4 K38 K39 Y72 R143 R158 R195 K196

External links

PDB	RCSB:8pj5, PDBe:8pj5, PDBj:8pj5
PDBsum	8pj5
PubMed
UniProt	Q14152\|EIF3A_HUMAN Eukaryotic translation initiation factor 3 subunit A (Gene Name=EIF3A)

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