Structure of PDB 8pj1 Chain t

Receptor sequence
>8pj1t (length=472) Species: 9606 (Homo sapiens) [Search protein sequence]
MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHV
AHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPE
CYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAA
VMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQA
KEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDF
TSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGI
VSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRA
DRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSK
NEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKH
WRLIGWGQIRRGVTIKPTVDDD
3D structure
PDB8pj1 Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining
Chaint
Resolution3.4 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna t R68 F69 Y83 R260 F262 D263 V264 P267 F322 E324 R68 F69 Y83 R260 F262 D263 V264 P267 F322 E324
BS02 GTP t V50 A51 H52 G53 K54 S55 T56 N76 I77 T78 G137 N190 K191 S225 A226 V50 A51 H52 G53 K54 S55 T56 N76 I77 T78 G137 N190 K191 S225 A226
BS03 MG t S55 T78 S55 T78
External links
PDB RCSB:8pj1, PDBe:8pj1, PDBj:8pj1
PDBsum8pj1
PubMed
UniProtP41091|IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 (Gene Name=EIF2S3)

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