Structure of PDB 6ff4 Chain t

Receptor sequence
>6ff4t (length=172) Species: 9606 (Homo sapiens) [Search protein sequence]
GVVYKSTRSAKPVGPEDMGATAVYELDTEKERDAQAIFERSQKIQEELRG
KEDDKIYRGINNYQRKGPIRAPEHLRATVRWDYQPDICKDYKETGFCGFG
DSCKFLHDRSDYKHGWQIERELDECFICRQSFQNPVVTKCRHYFCESCAL
QHFRTTPRCYVCDQQTNGVFNP
3D structure
PDB6ff4 Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Chaint
Resolution3.4 Å
3D
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna t I201 C202 K203 F213 C217 K218 F219 I87 C88 K89 F99 C103 K104 F105
BS02 ZN t C202 C211 C217 H221 C88 C97 C103 H107
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006281 DNA repair
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0016567 protein ubiquitination
GO:0034247 snoRNA splicing
GO:0070100 negative regulation of chemokine-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ff4, PDBe:6ff4, PDBj:6ff4
PDBsum6ff4
PubMed29361316
UniProtO15541|R113A_HUMAN E3 ubiquitin-protein ligase RNF113A (Gene Name=RNF113A)

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