Structure of PDB 8cq7 Chain s

Receptor sequence

>8cq7s (length=171) Species: 5476 (Candida albicans) [Search protein sequence]

KSQNVMRELRIEKLVLNICVGESGDRLTRAAKVLEQLSGQTPVQSKARYT
VRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYQLRSKNFSATGNFG
FGIDEHIDLGIKYDPSIGIYGMDFYVVMGRAGARVTRRKRARSTIGNSHK
TNKEDTIQWFKTRYDAEVLDK

3D structure

PDB

8cq7 Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Chain

Resolution

3.2 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	s	K16 V18 N20 C22 S48 A50 R51 Y52 F57 I59 A66 H68 K94 N95 S97 A98 T99 G103 F104 G105 G124 M125 D126 Y128 K142	K13 V15 N17 C19 S45 A47 R48 Y49 F54 I56 A63 H65 K91 N92 S94 A95 T96 G100 F101 G102 G121 M122 D123 Y125 K139
BS02	rna	s	K4 N7 M9 Q43 T44 V46 V69 T70 R72 G135 R137 R141 R143 S146 T147 G149 N150 H152	K1 N4 M6 Q40 T41 V43 V66 T67 R69 G132 R134 R138 R140 S143 T144 G146 N147 H149

External links

PDB	RCSB:8cq7, PDBe:8cq7, PDBj:8cq7
PDBsum	8cq7
PubMed
UniProt	A0A8H6F1S5

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