Structure of PDB 5xtc Chain s

Receptor sequence
>5xtcs (length=318) Species: 9606 (Homo sapiens) [Search protein sequence]
MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFA
DAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNL
GLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIIL
LSTLLMSGSFNLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRAPFDL
AEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNTLTTTIFLGTTYDAL
SPELYTTYFVTKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLAL
LMWHVSMPITISSIPPQT
3D structure
PDB5xtc Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
Chains
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLX s P295 M302 P295 M302
BS02 PLX s M183 M184 F186 L288 N292 M183 M184 F186 L288 N292
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0005515 protein binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0001666 response to hypoxia
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0009060 aerobic respiration
GO:0009410 response to xenobiotic stimulus
GO:0014070 response to organic cyclic compound
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0033194 response to hydroperoxide
GO:0042776 proton motive force-driven mitochondrial ATP synthesis
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0031966 mitochondrial membrane
GO:0043025 neuronal cell body
GO:0045271 respiratory chain complex I

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Molecular Function
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Cellular Component
External links
PDB RCSB:5xtc, PDBe:5xtc, PDBj:5xtc
PDBsum5xtc
PubMed28844695
UniProtP03886|NU1M_HUMAN NADH-ubiquinone oxidoreductase chain 1 (Gene Name=MT-ND1)

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