Structure of PDB 8ine Chain r

Receptor sequence

>8iner (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]

VVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRV
TNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLL
ARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTT
GNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVA
DYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEK
KPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLR

3D structure

PDB

8ine Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	r	K8 Y12 R15 Y16 K19 R23 Y31 R35 L36 K43 Y44 K48 F113 Y145 L150 R152 T153 F160 S176 R179 R268 Q275 D278 R279 Q282 K283 S286 R289	K3 Y7 R10 Y11 K14 R18 Y26 R30 L31 K38 Y39 K43 F108 Y140 L145 R147 T148 F155 S171 R174 R263 Q270 D273 R274 Q277 K278 S281 R284
BS02	rna	r	K10 F13 K14 V18 F20 R21 R22 R24 T28 Y30 R33 R50 I52 R54 T56 N57 R58 D59 Q63 I69 E70 D72 I74 G91 L92 N94 R152 T154 T155 K158 N203 Y207 Q222 S224 Q225 Y226 K256 E260 V261 K262 R265 W266 R268 P269 K270 M271 L273 R279	K5 F8 K9 V13 F15 R16 R17 R19 T23 Y25 R28 R45 I47 R49 T51 N52 R53 D54 Q58 I64 E65 D67 I69 G86 L87 N89 R147 T149 T150 K153 N198 Y202 Q217 S219 Q220 Y221 K251 E255 V256 K257 R260 W261 R263 P264 K265 M266 L268 R274

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding
GO:0031625	ubiquitin protein ligase binding
GO:0048027	mRNA 5'-UTR binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0010628	positive regulation of gene expression
GO:0042273	ribosomal large subunit biogenesis
GO:0045727	positive regulation of translation
GO:0050821	protein stabilization
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1904667	negative regulation of ubiquitin protein ligase activity
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435	negative regulation of protein neddylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0032991	protein-containing complex
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8ine, PDBe:8ine, PDBj:8ine
PDBsum	8ine
PubMed	37491604
UniProt	P46777\|RL5_HUMAN Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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