Structure of PDB 7v2r Chain r

Receptor sequence
>7v2rr (length=459) Species: 9823 (Sus scrofa) [Search protein sequence]
MLKIIIPTTMLLPMTWMSKHNMIWINATVHSLLISLISLSLLNQLGENSL
NFSLTFFSDSLSAPLLVLTTWLLPLMLMASQSHLSKETTTRKKLYITMLI
LLQLFLIMTFTATELILFYILFEATLVPTLIIITRWGNQTERLNAGLYFL
FYTLAGSLPLLVALVYIQNTTGSLNFLIIHYWSHPLSNSWSNIFMWLACI
MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRITTIL
NPLTNYMAYPFLMLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVA
IMIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERVHSRTMILARGLQT
LLPLMATWWLVASLTNLALPPSINLIGELFIITASFSWSNITIILMGMNM
MITALYSLYMLITTQRGKYTHHINNIKPSFTRENALMALHILPLLLLTLN
PKMILGPLY
3D structure
PDB7v2r The coupling mechanism of mammalian mitochondrial complex I.
Chainr
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLX r V67 L68 W71 L446 L447 N450 V67 L68 W71 L446 L447 N450
BS02 PLX r N188 W190 F261 N188 W190 F261
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0048039 ubiquinone binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0009060 aerobic respiration
GO:0015990 electron transport coupled proton transport
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0042773 ATP synthesis coupled electron transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Molecular Function
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Cellular Component
External links
PDB RCSB:7v2r, PDBe:7v2r, PDBj:7v2r
PDBsum7v2r
PubMed35145322
UniProtO79881|NU4M_PIG NADH-ubiquinone oxidoreductase chain 4 (Gene Name=MT-ND4)

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