Structure of PDB 5t2c Chain r

Receptor sequence

>5t2cr (length=210) Species: 9606 (Homo sapiens)

APSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPA
SGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPR
RRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLT
GPVMPVRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKE
AAEQDVEKKK

3D structure

• PDB: 5t2c Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
• Chain: r
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	r	N27 A30	N26 A29
BS02	rna	r	A2 S4 R5 M8 L10 K11 H13 F14 H15 K16 W18 W25 Q28 P29 R31 R34 R35 R36 R39 K42 R44 R56 V59 R60 C61 P62 R65 Y66 H67 R71 R74 L78 K88 D99 R101 R102 R103 R129 K135 R158 K162 K163 F179 R183 M184 R186 G193 I194 R198	A1 S3 R4 M7 L9 K10 H12 F13 H14 K15 W17 W24 Q27 P28 R30 R33 R34 R35 R38 K41 R43 R55 V58 R59 C60 P61 R64 Y65 H66 R70 R73 L77 K87 D98 R100 R101 R102 R128 K134 R157 K161 K162 F178 R182 M183 R185 G192 I193 R197

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0001824 blastocyst development
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0060348 bone development

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5t2c, PDBe:5t2c, PDBj:5t2c
• PDBsum: 5t2c
• PubMed: 27752045
• UniProt: P26373|RL13_HUMAN Large ribosomal subunit protein eL13 (Gene Name=RPL13)