Structure of PDB 5mu8 Chain r

Receptor sequence
>5mu8r (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]
PSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYL
IYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPP
WYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
3D structure
PDB5mu8 Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
Chainr
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JNI r S9 V13 H15 I155 S2 V6 H8 I142 BindingDB: IC50=1200nM
BS02 JNI r L57 G121 Y151 I155 L157 L50 G108 Y138 I142 L144 BindingDB: IC50=1200nM
Gene Ontology
Molecular Function
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5mu8, PDBe:5mu8, PDBj:5mu8
PDBsum5mu8
PubMed28300404
UniProtP01375|TNFA_HUMAN Tumor necrosis factor (Gene Name=TNF)

[Back to BioLiP]