Structure of PDB 7x3u Chain q

Receptor sequence
>7x3uq (length=523) Species: 9606 (Homo sapiens) [Search protein sequence]
KAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMV
INHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLV
FAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRD
IDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVDNIRVCK
ILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGT
VLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALHYAN
KYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVG
DTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDK
RLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENS
GVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGILDTYLGKYW
AIKLATNAAVTVLRVDQIIMAKP
3D structure
PDB7x3u Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM.
Chainq
Resolution3.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP q Y47 P49 D99 G100 N102 M169 S170 K171 G411 G412 I482 I497 D499 Y41 P43 D93 G94 N96 M163 S164 K165 G405 G406 I476 I491 D493
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0044183 protein folding chaperone
GO:0045296 cadherin binding
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051086 chaperone mediated protein folding independent of cofactor
GO:0061077 chaperone-mediated protein folding
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Cellular Component
GO:0002199 zona pellucida receptor complex
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005929 cilium
GO:0034774 secretory granule lumen
GO:0035578 azurophil granule lumen
GO:0044297 cell body
GO:0045111 intermediate filament cytoskeleton
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7x3u, PDBe:7x3u, PDBj:7x3u
PDBsum7x3u
PubMed37193829
UniProtP50990|TCPQ_HUMAN T-complex protein 1 subunit theta (Gene Name=CCT8)

[Back to BioLiP]