Structure of PDB 5k0y Chain q

Receptor sequence

>5k0yq (length=237) Species: 9986 (Oryctolagus cuniculus)

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVV
RISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGC
IVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKE
DDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTK
KNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSL

3D structure

• PDB: 5k0y eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
• Chain: q
• Resolution: 5.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	q	N4 P8 G11 Q13 L15 A33 S53 G55 N56 Q59 G60 P62 Q65 G66 L68 R72 R74 S82 C83 Y84 R85 R87 R88 T89 G90 R92 K93 R94 K95 S96 S107 V108 N110 K115 R131 R132 L133 G134 K136 R137 S139 R140 R142 K143 K149 E150 V153 R154 Q155 V157 R159 L162 E165 G166 K167 K168 P169 R170 T171 K172 A173 P174 K175 I176 Q177 R178 V180 T181 R183 Q186 H187 K188 R189 R190 R191 I192 K195 K196 R198 T199 N202 R224 E226 I228 K230 R231 R232 R233 S235 L237	N4 P8 G11 Q13 L15 A33 S53 G55 N56 Q59 G60 P62 Q65 G66 L68 R72 R74 S82 C83 Y84 R85 R87 R88 T89 G90 R92 K93 R94 K95 S96 S107 V108 N110 K115 R131 R132 L133 G134 K136 R137 S139 R140 R142 K143 K149 E150 V153 R154 Q155 V157 R159 L162 E165 G166 K167 K168 P169 R170 T171 K172 A173 P174 K175 I176 Q177 R178 V180 T181 R183 Q186 H187 K188 R189 R190 R191 I192 K195 K196 R198 T199 N202 R224 E226 I228 K230 R231 R232 R233 S235 L237

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019901 protein kinase binding

Biological Process

• GO:0000082 G1/S transition of mitotic cell cycle
• GO:0000278 mitotic cell cycle
• GO:0001890 placenta development
• GO:0002181 cytoplasmic translation
• GO:0002309 T cell proliferation involved in immune response
• GO:0006364 rRNA processing
• GO:0006412 translation
• GO:0006924 activation-induced cell death of T cells
• GO:0007369 gastrulation
• GO:0008284 positive regulation of cell population proliferation
• GO:0022605 mammalian oogenesis stage
• GO:0031929 TOR signaling
• GO:0033077 T cell differentiation in thymus
• GO:0042274 ribosomal small subunit biogenesis
• GO:0042593 glucose homeostasis
• GO:0043065 positive regulation of apoptotic process
• GO:0043066 negative regulation of apoptotic process
• GO:0048821 erythrocyte development

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0030425 dendrite
• GO:0032040 small-subunit processome
• GO:0036464 cytoplasmic ribonucleoprotein granule
• GO:0044297 cell body
• GO:0048471 perinuclear region of cytoplasm
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5k0y, PDBe:5k0y, PDBj:5k0y
• PDBsum: 5k0y
• PubMed: 27373335
• UniProt: G1TM55|RS6_RABIT Small ribosomal subunit protein eS6 (Gene Name=RPS6)